Micromilling of microbarbs for medical implants
Micromilling of microbarbs for medical implants
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DOI：
10.1016/j.ijmachtools.2007.08.020
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发表时间：
2008-03-01
影响因子：
14
通讯作者：
Ozdoganlar, O. B.
中科院分区：
文献类型：
--
作者：
Filiz, Sinan;Xie, Luke;Ozdoganlar, O. B.
许多植入式医疗设备的成功应用往往取决于将设备附着在活组织上的技术。尽管使用微尺度穿孔元件的机械连接技术非常有前途，但微尺度穿孔元件的制造仍面临相当大的挑战。本文研究了利用机械微铣削工艺制备生物相容性材料的微尺度穿刺元件（微倒刺）。在制造过程中使用了两个定制几何形状的微型铣刀。为了了解微铣削力、表面粗糙度和毛刺形成等性能指标的工艺条件，对聚甲基丙烯酸甲酯（PMMA）进行了实验设计研究。通过制造不同尺寸（宽度从68到174 μ m）、边缘锐度（60度和90度包括角度）和高度（84到460 μ m）的PMMA微倒刺，该工艺的几何能力得到了证明。通过使用不可生物降解的304不锈钢和PMMA、可生物吸收的聚乳酸（PLA）和纤维蛋白基塑料制造微倒钩，证明了微磨各种生物相容性材料的能力。结果表明，微铣削工艺可以有效地制备微倒刺阵列。(c) 2007 Elsevier Ltd.版权所有。
Successful application of many implantable medical devices often depends on the technique used for attaching the devices to living tissue. Although mechanical attachment techniques that use micro-scale piercing elements are very promising, the fabrication of the micro-scale piercing elements poses considerable challenges. In this paper, the use of the mechanical micromilling process for fabrication of micro-scale piercing elements (microbarbs) from biocompatible materials is investigated. Two micro-scale milling tools with custom geometries are used during the fabrication. To gain an understanding of the process conditions on the performance metrics of micromilling forces, surface roughness, and burr formation, a design of experiments study is performed on polymethyl methacrylate (PMMA). The geometric capability of the process is demonstrated by fabricating PMMA microbarbs with different sizes (widths from 68 to 174 mu m), edge sharpnesses (60 degrees and 90 degrees included angles), and heights (from 84 to 460 mu m). The capability to micromill a variety of biocompatible materials is demonstrated by creating microbarbs from non-biodegradable 304 stainless steel and PMMA, from bioresorbable polylactic acid (PLA), and from a fibrin based plastic. It is concluded that the micromilling process can be used for effectively fabricating arrays of microbarbs. (c) 2007 Elsevier Ltd. All rights reserved.