Protein, as a Regulator of Pancreatic Enzyme Secretion in the Rat 1
Protein, as a Regulator of Pancreatic Enzyme Secretion in the Rat 1
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蛋白质作为大鼠胰酶分泌的调节剂 1
DOI：
10.3181/00379727-142-37199
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发表时间：
1973
影响因子：
--
通讯作者：
R. Lyman
中科院分区：
文献类型：
--
作者：
G. Green;B. A. Olds;Glenda Matthews;R. Lyman
在清醒的恢复大鼠中研究了胰酶分泌，通过插管直接收集胆胰液。当收集胆胰液并连续返回肠道时，蛋白质的引入引起酶分泌的显着增加，而蛋白质水解产物不是有效的刺激物。胆胰液的分流，或大豆胰蛋白酶抑制剂的引入，导致酶分泌的非常大的增加。结果支持了胰酶分泌负反馈控制的概念，并提出蛋白质通过减少肠中胰蛋白酶和糜蛋白酶产生的反馈抑制来刺激胰酶分泌增加。提交人对Raul Reyes的技术援助表示感谢。
Summary Pancreatic enzyme secretion was studied in conscious, recovered rats with bile-pancreatic juice collected directly via a cannula. When bile-pancreatic juice was collected and continuously returned to the intestine, introduction of protein evoked a marked increase in enzyme secretion, while protein hydrolysates were not effective stimulants. Diversion of bile-pancreatic juice, or introduction of soybean trypsin inhibitor, resulted in very large increases in enzyme secretion. The results support the concept of negative feedback control of pancreatic enzyme secretion, and it is proposed that protein stimulates increased pancreatic enzyme secretion by reducing feedback inhibition produced by trypsin and chymotrypsin in the intestine. The authors express their thanks to Raul Reyes for his technical assistance.