Compton imaging with 99mTc for human imaging
Compton imaging with 99mTc for human imaging
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DOI：
10.1038/s41598-019-49130-z
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发表时间：
2019-09-09
影响因子：
4.6
通讯作者：
Nakano, Takashi
中科院分区：
文献类型：
--
作者：
Sakai, Makoto;Kubota, Yoshiki;Nakano, Takashi
我们已经开发了一种使用康普顿照相机的医学成像系统，并证明了康普顿照相机对大鼠肾脏中蓄积的Tc-99 m-DMSA的成像能力。在这项研究中，我们使用人体模型进行成像实验，以确认其适用于人体成像。初步模拟进行了使用不同的活动比之间的肾脏和躯干区域的数字体模。伽马射线（141千电子伏）产生和检测的康普顿相机的硅和碲化镉（Si/CdTe）探测器的基础上。采用列表模式中值根先验期望最大化法重建康普顿图像。通过模拟确认了该条件的适当迭代次数。重建的康普顿图像显示肾脏区域有两个亮点。此外，通过对感兴趣区域内的像素值进行积分而计算的数值与肾脏区域的活性良好相关。最后，进行了实验研究，以确定模拟研究的结果是否可以复制。肾脏可以成功可视化。总之，考虑到本研究中的条件符合典型人体和可想象的实验装置，Si/CdTe康普顿相机在人体成像中具有很高的成功概率。此外，我们的研究结果表明，（半）定量分析的能力，使用康普顿图像。
We have been developing a medical imaging system using a Compton camera and demonstrated the imaging ability of Compton camera for Tc-99m-DMSA accumulated in rat kidneys. In this study, we performed imaging experiments using a human body phantom to confirm its applicability to human imaging. Preliminary simulations were conducted using a digital phantom with varying activity ratios between the kidney and body trunk regions. Gamma rays (141 keV) were generated and detected by a Compton camera based on a silicon and cadmium telluride (Si/CdTe) detector. Compton images were reconstructed with the list mode median root prior expectation maximization method. The appropriate number of iterations of the condition was confirmed through simulations. The reconstructed Compton images revealed two bright points in the kidney regions. Furthermore, the numerical value calculated by integrating pixel values inside the region of interest correlated well with the activity of the kidney regions. Finally, experimental studies were conducted to ascertain whether the results of the simulation studies could be reproduced. The kidneys could be successfully visualised. In conclusion, considering that the conditions in this study agree with those of typical human bodies and imaginable experimental setup, the Si/CdTe Compton camera has a high probability of success in human imaging. In addition, our results indicate the capability of (semi-) quantitative analysis using Compton images.