Facile and efficient synthesis of 2-substituted-N1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent
Facile and efficient synthesis of 2-substituted-N1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones in fluorous solvent
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DOI：
10.1016/j.cclet.2008.03.022
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发表时间：
2008-05
影响因子：
9.1
通讯作者：
Bailing Xu;J. Chen;R. Qiao;D. Fu
中科院分区：
文献类型：
--
作者：
Bailing Xu;J. Chen;R. Qiao;D. Fu
以对甲苯磺酸为催化剂，在2，2，2-三氟乙醇或六氟异丙醇中，通过取代N-乙氧羰基邻氨基苯甲酰胺与烷基醛、芳香醛或杂芳香醛缩合，合成了2-取代-N1-乙氧羰基-2，3-二氢-4（1H）-喹唑啉酮。
A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4(1H)-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2-trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.