The dynamics of mitochondrial autophagy at the initiation stage.
The dynamics of mitochondrial autophagy at the initiation stage.
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DOI：
10.1042/bst20210272
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发表时间：
2021-11-01
影响因子：
3.9
通讯作者：
Ktistakis NT
中科院分区：
文献类型：
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作者：
Ktistakis NT
线粒体特异性自噬（mitophagy，在此定义为在不同的线粒体损伤或发育/代谢改变后线粒体的特异性消除）的途径在健康和疾病中很重要。这篇评论将集中在最早的步骤的途径有关的机制和要求启动自噬体形成的线粒体目标。更具体地说，鉴于我们了解非选择性自噬的基本机制，并开始将这些知识重塑为选择性自噬的途径，我们将涵盖线粒体自噬的两个方面：（i）一个机器如何正常工作与内质网（ER）自噬体也可以在与ER不同的位点上产生，例如在靶向货物的表面上？及（ii）机械如何处理多种尺寸的货物？
The pathway of mitochondrial-specific autophagy (mitophagy, defined here as the specific elimination of mitochondria following distinct mitochondrial injuries or developmental/metabolic alterations) is important in health and disease. This review will be focussed on the earliest steps of the pathway concerning the mechanisms and requirements for initiating autophagosome formation on a mitochondrial target. More specifically, and in view of the fact that we understand the basic mechanism of non-selective autophagy and are beginning to reshape this knowledge towards the pathways of selective autophagy, two aspects of mitophagy will be covered: (i) How does a machinery normally working in association with the endoplasmic reticulum (ER) to make an autophagosome can also do so at a site distinct from the ER such as on the surface of the targeted cargo? and (ii) how does the machinery deal with cargo of multiple sizes?