Volumetric differences suggest involvement of cerebellum and brainstem in chronic migraine
Volumetric differences suggest involvement of cerebellum and brainstem in chronic migraine
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DOI：
10.1177/0333102415588328
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发表时间：
2016-04-01
期刊：
影响因子：
4.9
通讯作者：
Baykan, Betul
中科院分区：
文献类型：
--
作者：
Bilgic, Basar;Kocaman, Gulsen;Baykan, Betul
慢性偏头痛（CM）是一种致残性神经系统疾病，通常由发作性偏头痛演变而来。有越来越多的证据表明偏头痛患者的磁共振成像（MRI）技术检测到的体积变化。这些研究主要集中在发作性偏头痛患者和较少是已知的CM patients.Method的差异，共24 CM患者和24名健康对照个体（所有女性）被纳入本研究。所有受试者均接受神经系统检查和MRI检查。使用自动分割方法（FreeSurfer）处理高分辨率解剖MRI图像。白质异常的大脑也进行了评估与脑白质相关的变化Scale.Results小脑和脑干的体积被发现是较小的CM患者相比，健康对照组。白质异常也被发现在CM患者，特别是在双侧顶枕区。有没有相关性的临床变量和体积减少在这些regions.ConclusionCM患者表现出显着的体积差异幕下区和白质异常的后部大脑。目前尚不清楚偏头痛患者的大脑结构变化是头痛的原因还是结果。需要更大组的纵向容积神经影像学研究，特别是偏头痛的慢性化，以阐明这一主题。
Background Chronic migraine (CM) is a disabling neurologic condition that often evolves from episodic migraine. There has been mounting evidence on the volumetric changes detected by magnetic resonance imaging (MRI) technique in migraineurs. These studies mainly focused on episodic migraine patients and less is known about the differences in CM patients.Method A total of 24 CM patients and 24 healthy control individuals (all females) were included in this study. All participants underwent neurological examination and MRI. High-resolution anatomical MRI images were processed with an automated segmentation method (FreeSurfer). White-matter abnormalities of the brain were also evaluated with the Age-Related White-Matter-Changes Scale.Results The volumes of the cerebellum and brainstem were found to be smaller in CM patients compared to healthy controls. White-matter abnormalities were also found in CM patients, specifically in the bilateral parieto-occipital areas. There was no correlation between the clinical variables and volume decrease in these regions.Conclusion CM patients showed significant volume differences in infratentorial areas and white-matter abnormalities in the posterior part of the brain. It is currently unclear whether the structural brain changes seen in migraine patients are the cause or the result of headaches. Longitudinal volumetric neuroimaging studies with larger groups, especially on the chronification of migraine, are needed to shed light on this topic.