High-frequency oscillations are prominent in the extended amygdala
High-frequency oscillations are prominent in the extended amygdala
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DOI：
10.1152/jn.00107.2014
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发表时间：
2014-07-01
影响因子：
2.5
通讯作者：
Pare, Denis
中科院分区：
文献类型：
--
作者：
Haufler, Darrell;Pare, Denis
以前，据报道，各种皮质和皮质下结构显示高频局部场电位（LFP）振荡在110至160 Hz范围（HFO），从尖锐波波纹不同。在本研究中，我们的特点HFOs在扩展杏仁核。将四极束植入大鼠终纹床核（BNST）、中央杏仁核（CeA）以及邻近区域（苍白球、尾壳核和外侧隔）。在所有记录的网站，HFO功率表现出系统的行为状态的依赖性：最高在安静的觉醒，中间在异相睡眠，最低在活跃的觉醒或慢波睡眠。CO2窒息以及异氟烷或乌拉坦麻醉可消除HFO。HFO相对于所有其他快频率LFP成分脱颖而出，因为它们在同侧和对侧的扩展杏仁核的远端部位之间高度一致。HFO以两种方式影响神经元放电：放电率可以作为HFO功率的函数而变化（速率调制），或者HFO可以在周期到周期的基础上夹带放电（相位调制）。在BNST和CeA中，相位调制神经元的发生率（20-40%）比邻近区域高出约两倍（
Previously, it was reported that various cortical and subcortical structures display high-frequency local field potential (LFP) oscillations in the 110- to 160-Hz range (HFOs), distinct from sharp-wave ripples. In the present study, we characterize HFOs in the extended amygdala. Rats were implanted with tetrode bundles in the bed nucleus of the stria terminalis (BNST), central amygdala (CeA), as well as adjacent regions (pallidum, caudate-putamen, and lateral septum). At all recorded sites, HFO power showed a systematic dependence on behavioral state: highest during quiet wakefulness, intermediate during paradoxical sleep, and lowest during active waking or slow-wave sleep. CO2 asphyxiation as well as anesthesia with isoflurane or urethane abolished HFOs. HFOs stood out relative to all other fast-frequency LFP components because they were highly coherent between distant sites of the extended amygdala, ipsi- and contralaterally. HFOs affected neuronal firing in two ways: firing rate could vary as a function of HFO power (rate modulation) or HFOs could entrain firing on a cycle-to-cycle basis (phase modulation). The incidence of phase-modulated neurons was about twice higher in BNST and CeA (20-40%) than in adjacent regions (