Particle size distribution of selected electronic nicotine delivery system products
Particle size distribution of selected electronic nicotine delivery system products
复制标题
DOI：
10.1016/j.fct.2018.01.045
复制
发表时间：
2018-03-01
影响因子：
4.3
通讯作者：
Gardner, William P.
中科院分区：
文献类型：
--
作者：
Oldham, Michael J.;Zhang, Jingjie;Gardner, William P.
剂量学模型可以用来预测吸入物质的剂量，但它们需要包括颗粒大小分布在内的几个参数。已报道的电子尼古丁递送系统(END)产品的气雾剂颗粒尺寸分布差异很大，并不总是能识别特定的产品。使用低流量串级冲击器测定了20种不同弹丸终端产品的颗粒尺寸分布[质量中值空气动力学直径(MMAD)；几何标准差(GSD)]。为了评估损失和汽相量，通过比较冲击器中收集的质量和最终产品质量的差异来测量系统的收集效率。还测量了每种产品配方中的尼古丁、甘油、丙二醇、水和薄荷脑的水平。无论最终产品配方如何，所有受试产品的MMAD相似，范围为0.9至1.2微米，GSD为1.7至2.2。MMAD和GSD没有作为喷雾次数(弹丸寿命)的函数的一致变化模式。收集效率表明，产生的质量的9%-26%沉积在收集系统中或处于汽相中。这些颗粒尺寸分布数据适用于气溶胶剂量测量程序。
Dosimetry models can be used to predict the dose of inhaled material, but they require several parameters including particle size distribution. The reported particle size distributions for aerosols from electronic nicotine delivery system (ENDS) products vary widely and don't always identify a specific product. A low-flow cascade impactor was used to determine the particle size distribution [mass median aerodynamic diameter (MMAD); geometric standard deviation (GSD)] from 20 different cartridge based ENDS products. To assess losses and vapor phase amount, collection efficiency of the system was measured by comparing the collected mass in the impactor to the difference in ENDS product mass. The levels of nicotine, glycerin, propylene glycol, water, and menthol in the formulations of each product were also measured. Regardless of the ENDS product formulation, the MMAD of all tested products was similar and ranged from 0.9 to 1.2 mu m with a GSD ranging from 1.7 to 2.2. There was no consistent pattern of change in the MMAD and GSD as a function of number of puffs (cartridge life). The collection efficiency indicated that 9%-26% of the generated mass was deposited in the collection system or was in the vapor phase. The particle size distribution data are suitable for use in aerosol dosimetry programs.