Molecular and cellular targets
Molecular and cellular targets
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DOI：
10.1002/mc.20222
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发表时间：
2006-06-01
影响因子：
4.6
通讯作者：
Dong, Zigang
中科院分区：
文献类型：
--
作者：
Bode, Ann M.;Dong, Zigang
癌变是一个多阶段的过程，包括起始阶段、促进阶段和进展阶段，每个阶段都可能成为化学预防药物的靶点。这些研究在阐明分子和细胞机制方面的一个重要成果是阐明了肿瘤促进剂在癌症发展中诱导的信号转导途径。目前的观点是，可以通过靶向特定的癌症基因、信号蛋白和转录因子来预防或治疗癌症。解释正常细胞如何在肿瘤促进剂诱导下发生肿瘤转化的分子机制正在迅速被阐明。越来越多的研究证据表明，包括茶化合物在内的许多饮食因素可以单独使用，也可以与传统化疗药物联合使用，以预防或治疗癌症。许多天然或饮食化合物的潜在优势似乎集中在它们强大的抗癌活性，以及低毒和极少的不良副作用。这篇综述总结了我们最近关于茶叶各种成分对肿瘤细胞转化和致癌过程中的信号转导途径的影响的一些工作。(C)2006年Wiley-Liss，Inc.
Carcinogenesis is a multistage process consisting of initiation, promotion, and progression stages and each stage may be a possible target for chemopreventive agents. A significant outcome of these investigations on the elucidation of molecular and cellular mechanisms is the explication of signal transduction pathways induced by tumor promoters in cancer development. The current belief today is that cancer may be prevented or treated by targeting specific cancer genes, signaling proteins, and transcription factors. The molecular mechanisms explaining how normal cells undergo neoplastic transformation induced by tumor promoters are rapidly being clarified. Accumulating research evidence suggests that many of dietary factors, including tea compounds, may be used alone or in combination with traditional chemotherapeutic agents to prevent or treat cancer. The potential advantage of many natural or dietary compounds seems to focus on their potent anticancer activity combined with low toxicity and very few adverse side effects. This review summarizes some of our recent work regarding the effects of the various tea components on signal transduction pathways involved in neoplastic cell transformation and carcinogenesis. (c) 2006 Wiley-Liss, Inc.