B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes

B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes
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B 细胞刺激因子 1(白细胞介素 4)是正常静息 T 淋巴细胞的有效共刺激剂

DOI:
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发表时间:
1987
影响因子:
15.3
通讯作者:
W. Paul
W. Paul
中科院分区:
医学1区
文献类型:
--
作者:
J. Hu‐Li;E. Shevach;J. Mizuguchi;J. Ohara;T. Mosmann;W. Paul

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静止T细胞在B细胞刺激因子1 (BSF-1;白细胞介素4)和肉豆蔻酸酯磷(PMA)的作用下增殖。这种反应是用高度纯化的T细胞获得的,并且与密度无关,这表明不需要辅助细胞。L3T4+和Lyt-2+ T细胞对BSF-1 + PMA均有反应。虽然BSF-1单独不引起T细胞增殖,但它能维持小而致密的T细胞的活力,这表明它对静止的T细胞起作用。此外,静止T细胞对BSF-1 + PMA的增殖反应早期需要BSF-1,进一步支持其作用于G0或早期G1细胞的概念。然而,在BSF-1 + PMA刺激的T细胞第一轮分裂后期也需要BSF-1。在刺激24小时去除BSF-1可防止进入S期。这些结果表明,BSF-1既参与诱导能力,也参与T细胞分裂的进展阶段。
Resting T cells proliferate in response to B cell stimulatory factor 1 (BSF-1; interleukin 4) plus phorbol myristate acetate (PMA). This response is obtained with highly purified T cells and is density independent, suggesting that accessory cells are not required. Both L3T4+ and Lyt-2+ T cells respond to BSF-1 plus PMA. Although BSF-1 alone does not cause T cell proliferation, it maintains the viability of small, dense T cells, indicating that it acts on resting T cells. Furthermore, BSF-1 is required early in the proliferative response of resting T cells to BSF-1 plus PMA, further supporting the concept that it acts on G0 or early G1 cells. However, BSF-1 is also needed late in the first round of division of T cells stimulated with BSF-1 plus PMA. Removing BSF-1 at 24 h of stimulation prevents entry into S phase. These results indicate that BSF-1 is involved in both the induction of competence and in the progression phases of T cell division.
DOI: 10.4049/jimmunol.127.6.2488
发表时间: 1981-12
影响因子: 4.4
作者:
A. Bhattacharya;M. Dorf;T. Springer
通讯作者: A. Bhattacharya;M. Dorf;T. Springer
磷脂酰肌醇代谢增加是 B 淋巴细胞激活的一个重要但不是必需的早期事件。
DOI: --
发表时间: 1985
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Grupp,SA;Harmony,JA
通讯作者: Harmony,JA
用佛波醇 12-肉豆蔻酸酯 13-乙酸酯处理的 GH3 细胞中免疫沉淀蛋白激酶 C 的命运。
DOI: --
发表时间: 1985
期刊: The Journal of biological chemistry
影响因子: --
作者:
Ballester,R;Rosen,OM
通讯作者: Rosen,OM
干扰素-γ 抑制 B 细胞刺激因子 (BSF)-1 对静息 B 细胞的作用。
DOI: --
发表时间: 1986
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Rabin,EM;Mond,JJ;Ohara,J;Paul,WE
通讯作者: Paul,WE