B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes
B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes
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B 细胞刺激因子 1(白细胞介素 4)是正常静息 T 淋巴细胞的有效共刺激剂
DOI:
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发表时间:
1987
影响因子:
15.3
通讯作者:
W. Paul
中科院分区:
文献类型:
--
作者:
J. Hu‐Li;E. Shevach;J. Mizuguchi;J. Ohara;T. Mosmann;W. Paul
Resting T cells proliferate in response to B cell stimulatory factor 1 (BSF-1; interleukin 4) plus phorbol myristate acetate (PMA). This response is obtained with highly purified T cells and is density independent, suggesting that accessory cells are not required. Both L3T4+ and Lyt-2+ T cells respond to BSF-1 plus PMA. Although BSF-1 alone does not cause T cell proliferation, it maintains the viability of small, dense T cells, indicating that it acts on resting T cells. Furthermore, BSF-1 is required early in the proliferative response of resting T cells to BSF-1 plus PMA, further supporting the concept that it acts on G0 or early G1 cells. However, BSF-1 is also needed late in the first round of division of T cells stimulated with BSF-1 plus PMA. Removing BSF-1 at 24 h of stimulation prevents entry into S phase. These results indicate that BSF-1 is involved in both the induction of competence and in the progression phases of T cell division.
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影响因子:
4.4
作者:
A. Bhattacharya;M. Dorf;T. Springer
通讯作者:
A. Bhattacharya;M. Dorf;T. Springer
DOI:
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发表时间:
1985
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Grupp,SA;Harmony,JA
通讯作者:
Harmony,JA
DOI:
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发表时间:
1985
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
Ballester,R;Rosen,OM
通讯作者:
Rosen,OM
DOI:
--
发表时间:
1986
期刊:
Journal of immunology (Baltimore, Md. : 1950)
影响因子:
--
作者:
Rabin,EM;Mond,JJ;Ohara,J;Paul,WE
通讯作者:
Paul,WE