Haptoglobin, inflammation, and tumorigenesis in the MIN mouse
Haptoglobin, inflammation, and tumorigenesis in the MIN mouse
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DOI：
10.1179/135100001101536553
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发表时间：
2001-01-01
期刊：
影响因子：
3.8
通讯作者：
Berger, FG
中科院分区：
文献类型：
--
作者：
Barbour, KW;Davis, T;Berger, FG
我们已经确定，MIN小鼠，这是易患腺瘤的小肠和大肠，表现出慢性炎症的特点是诱导触珠蛋白（HP），以及其他急性期蛋白。炎症在约40-70日龄时开始，并在动物的整个生命中维持。由饮食引起的炎症延迟发作与肿瘤数量减少和寿命延长有关。缺乏触珠蛋白的基因敲除小鼠表现出肿瘤数量的增加，表明急性期反应物抑制肿瘤发生，可能是通过抑制炎症反应。因此，MIN小鼠是研究HP和炎症在体内肿瘤发生中的作用的有用模型。
We have determined that the MIN mouse, which is predisposed to adenomas of the small and large intestine, exhibits chronic inflammation characterized by the induction of haptoglobin (HP), as well as other acute phase proteins. Inflammation is initiated at about 40-70 days of age, and is maintained throughout the life of the animal. Delayed onset of inflammation brought on by dietary means is associated with a reduction in tumor number and longer life-span. Knockout mice that lack haptoglobin exhibit an increase in tumor number, indicating that the acute phase reactant suppresses tumorigenesis, perhaps through inhibition of the inflammatory response. The MIN mouse is, therefore, a useful model for studying the roles of HP and inflammation in tumorigenesis in vivo.