Safety and protective effect of Lactobacillus acidophilus and Lactobacillus casei used as probiotic agent in vivo
Safety and protective effect of Lactobacillus acidophilus and Lactobacillus casei used as probiotic agent in vivo
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DOI：
10.5897/ajb2003.000-1090
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发表时间：
2003-11
影响因子：
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通讯作者：
.. V.O.Oyetayo-V.O.Oyetayo-1403690161;F. Adetuyi;F. Akinyosoye
中科院分区：
文献类型：
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作者：
.. V.O.Oyetayo-V.O.Oyetayo-1403690161;F. Adetuyi;F. Akinyosoye
对从新鲜牛奶中分离出的嗜酸乳杆菌和干酪乳杆菌的保护作用进行了体内研究。大鼠血清毒理学数据表明，分离的乳杆菌具有改善肝脏的功能。单独服用乳杆菌分离株的大鼠的血清丙氨酸转氨酶（ALT）活性低于对照（15.50 和 18.27 iu/l）。经过 3 天的喂养试验后，给予干酪乳杆菌的大鼠的肠细菌数量有所减少。还观察到这些分离株对胃肠道（GIT）的保护作用。组织病理学数据证实，给予乳杆菌分离株并同时感染大肠杆菌的大鼠的胃肠道受到部分保护。一般认为干酪乳杆菌在改善肝功能、抗胆固醇作用和减少胃肠道肠杆菌方面比嗜酸乳杆菌具有更好的效果。关键词：益生菌，保护，乳酸菌。
The protective effect of Lactobacillus acidophilus and Lactobacillus casei, isolated from fresh cow milk, was studied in vivo. Toxicological data of rat serum revealed that the Lactobacillus isolates had liver improvement functions. Serum alanine aminotransferase (ALT) activities of the rats dosed with Lactobacillus isolates alone were lower (15.50 and 18.27 iu/l) than the control. There was a reduction in the count of enterobacteria in rats dosed with L. casei after 3 days of feeding trials. Protection of the gastrointestinal tract (GIT) by these isolates was also observed. Histopathological data confirmed partial protection of the GIT in rats dosed with Lactobacillus isolates and simultaneously infected with Escherichia coli. L. casei was generally observed to have a better effect than L. acidophilus in terms of liver function improvement, anticholesterolaemic effect, and reduction of enterobacteria in the GIT. Key words: Probiotic, protection, Lactobacillus.