Outward subcortical curvature associated with sub-clinical depression symptoms in adolescents
Outward subcortical curvature associated with sub-clinical depression symptoms in adolescents
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DOI：
10.1016/j.nicl.2020.102187
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发表时间：
2020-01-01
影响因子：
4.2
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Jenkins, Lisanne M.;Chiang, Jessica J.;Wang, Lei
目的：亚临床或阈值下抑郁症状(STD)常见于青春期，与成年后自杀和抑郁发作有关，但其神经生物学机制尚不清楚。方法：对277名来自芝加哥的14岁青少年进行结构磁共振扫描，并完成修订的儿童焦虑和抑郁量表(RCADS)。血液样本提供了五种促炎细胞因子的混合物。用于基于顶点的表面分析的感兴趣区(ROI)是左右杏仁核、海马体、丘脑、尾状核、伏隔核、苍白球和壳核。协变量为年龄、青春期状况、社会经济劣势和颅内体积。结果：STD与女性右侧杏仁核和左侧海马区皮质下形态呈正相关，男性与双侧壳核和左侧尾状核、海马区和丘脑呈正相关。然而，我们还发现，女性海马区的STD(向内收缩)和男性的尾状核与STD呈负相关。结论：本研究首次对青少年STD相关的基底节和丘脑皮质下形态进行了研究，并首次报道了青少年STD与体积和外在形态之间的正相关关系。这些发现可能反映了完整的神经发生或对抑郁的弹性，但需要进行纵向研究来进一步了解青少年性传播疾病的神经生物学。
Objective: Subclinical or subthreshold depressive symptoms (StD) are frequent in adolescence and are related to suicidality and onset of depression in adulthood, however, their neurobiology is poorly understood. We examined the relationship between StD and subcortical grey matter structures in unmedicated adolescents with no history of axis I diagnosis.Methods: 277 youths from Chicago aged 14 years participated, undergoing a structural MRI scan and completing the Revised Children's Anxiety and Depression Scale (RCADS). Blood samples provided a composite of five proinflammatory cytokines. Regions of interest (ROI) for vertex-based surface analysis were the left and right amygdala, hippocampus, thalamus, caudate, nucleus accumbens, pallidum and putamen. Covariates were age, pubertal status, socioeconomic disadvantage and intracranial volume. Males and females were analysed separately.Results: StD had positive associations (outward shape) with subcortical morphology in the right amygdala and left hippocampus in females, and the bilateral putamen and the left caudate, hippocampus and thalamus in males. However, we also found negative associations with StD (inward contractions) in the hippocampus in females and the caudate in males. Pro-inflammatory cytokines did not mediate the relationship between StD and outward morphology or volume.Conclusion: This is one of the first studies to examine subcortical morphology of basal ganglia and thalamic regions related to StD in adolescents, and the first study to report mostly positive associations between StD, volume and outward morphology in youths. These findings could reflect intact neurogenesis or resilience to depression, however longitudinal research is needed to further understand the neurobiology of StD in adolescents.