Repair of long intercalated rib defects using porous beta-tricalcium phosphate cylinders containing recombinant human bone morphogenetic protein-2 in dogs
Repair of long intercalated rib defects using porous beta-tricalcium phosphate cylinders containing recombinant human bone morphogenetic protein-2 in dogs
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DOI：
10.1016/j.biomaterials.2006.04.044
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发表时间：
2006-10-01
期刊：
影响因子：
14
通讯作者：
Takaoka, Kunio
中科院分区：
文献类型：
--
作者：
Hoshino, Masatoshi;Egi, Takeshi;Takaoka, Kunio
提出了一种新的含有重组人骨形态发生蛋白-2(rhBMP-2)的生物材料修复肋骨缺损的方法。我们以前曾报道过，通过在完整的骨膜上放置一条短链的小的β-磷酸三钙(β-TCP)圆柱体，成功地再生了肋骨的骨缺损。当无骨膜时，多柱体种植体对促进肋骨修复无效。通过将重组人骨形态发生蛋白-2添加到β-磷酸三钙圆柱体中，我们能够在有或没有骨膜的情况下促进肋骨的再生。在犬模型中评价重组人骨形态发生蛋白-2/β-磷酸三钙复合种植体的成骨能力和完成再生所需的时间。取一段8厘米长的肋骨，包括骨膜，代之以一串重组人骨形态发生蛋白-2/β-磷酸三钙圆柱体。植入后6周，肋骨恢复到原来的形态和机械强度。在12周内，多柱体β-磷酸三钙种植体降解，并被新骨取代。这种新型可降解骨诱导植入材料在肋骨修复中具有重要的临床应用潜力。(C)2006爱思唯尔有限公司。保留所有权利。
A new method to repair rib defects with biomaterials containing recombinant human bone morphogenetic protein-2 (rhBMP-2) is presented in this report. We had reported previously the successful regeneration of bony rib defects by placing a short chain of small beta-tricalcium phosphate (beta-TCP) cylinders on the intact periosteum. The multi-cylinder implants were ineffective in promoting rib repair when the periosteum was absent. By adding rhBMP-2 to the beta-TCP cylinders, we were able to promote rib bone regeneration in the presence or absence of the periosteum. The osteogenic capacity of the rhBMP-2/beta-TCP composite implant and the time required to complete regeneration were evaluated in a canine model. An 8 cm long section of rib bone, including the periosteum, was removed and replaced with a chain of the rhBMP-2/beta-TCP cylinders. At 6 weeks after implantation, the ribs were restored to their original configuration and mechanical strength. The multi-cylinder beta-TCP implants were degraded and replaced by new bone in 12 weeks. This new degradable bone-inducing implant material has significant clinical potential for rib repair. (c) 2006 Elsevier Ltd. All rights reserved.