Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment.
Multiregion transcriptomic profiling of the primate brain reveals signatures of aging and the social environment.
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DOI：
10.1038/s41593-022-01197-0
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发表时间：
2022-12
影响因子：
25
通讯作者：
Snyder-Mackler N
中科院分区：
文献类型：
--
作者：
Chiou KL;DeCasien AR;Rees KP;Testard C;Spurrell CH;Gogate AA;Pliner HA;Tremblay S;Mercer A;Whalen CJ;Negrón-Del Valle JE;Janiak MC;Bauman Surratt SE;González O;Compo NR;Stock MK;Ruiz-Lambides AV;Martínez MI;Cayo Biobank Research Unit;Wilson MA;Melin AD;Antón SC;Walker CS;Sallet J;Newbern JM;Starita LM;Shendure J;Higham JP;Brent LJN;Montague MJ;Platt ML;Snyder-Mackler N
衰老伴随着一系列与行为、认知健康和神经退行性疾病易感性相关的社会和生物变化。为了了解灵长类动物大脑老化的轨迹，我们生成了一个多区域批量(N=527个样本)和单核(N=24个样本)脑转录数据集，在一个独特的自由放养、行为表型恒河猴群体中包含15个大脑区域和性别。我们证明，与神经功能和神经疾病(包括阿尔茨海默病)相关的基因表达水平和变化与年龄相关。此外，我们还表明，女性较高的社会地位与较年轻的相对转录年龄有关，这提供了社会环境和大脑老化之间的联系。我们的发现有助于深入了解人类行为、认知和健康的非人类灵长类动物模型中大脑老化的生物学机制。
Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 brain regions and both sexes in a unique population of free-ranging, behaviorally phenotyped rhesus macaques. We demonstrate that age-related changes in the level and variance of gene expression occur in genes associated with neural functions and neurological diseases, including Alzheimer’s disease. Further, we show that higher social status in females is associated with younger relative transcriptional ages, providing a link between the social environment and aging in the brain. Our findings lend insight into biological mechanisms underlying brain aging in a nonhuman primate model of human behavior, cognition and health.
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影响因子：
64.8
作者：
Cao, Junyue;Spielmann, Malte;Shendure, Jay
通讯作者：
Shendure, Jay
影响因子：
4.3
作者：
Deleidi M;Jäggle M;Rubino G
通讯作者：
Rubino G
影响因子：
9.8
作者：
Allen, Mariet;Carrasquillo, Minerva M.;Funk, Cory;Heavner, Benjamin D.;Zou, Fanggeng;Younkin, Curtis S.;Burgess, Jeremy D.;Chai, High-Seng;Crook, Julia;Eddy, James A.;Li, Hongdong;Logsdon, Ben;Peters, Mette A.;Dang, Kristen K.;Wang, Xue;Serie, Daniel;Wang, Chen;Thuy Nguyen;Lincoln, Sarah;Malphrus, Kimberly;Bisceglio, Gina;Li, Ma;Golde, Todd E.;Mangravite, Lara M.;Asmann, Yan;Price, Nathan D.;Petersen, Ronald C.;Graff-Radford, Neill R.;Dickson, Dennis W.;Younkin, Steven G.;Ertekin-Taner, Nilufer
通讯作者：
Ertekin-Taner, Nilufer
DOI：
10.1073/pnas.1507125112
发表时间：
2015-06-09
影响因子：
11.1
作者：
Darmanis S;Sloan SA;Zhang Y;Enge M;Caneda C;Shuer LM;Hayden Gephart MG;Barres BA;Quake SR
通讯作者：
Quake SR
影响因子：
9.8
作者：
De Jager, Philip L.;Ma, Yiyi;Bennett, David A.
通讯作者：
Bennett, David A.