Cyclin D1, EMS1 and 11q13 amplification in breast cancer
Cyclin D1, EMS1 and 11q13 amplification in breast cancer
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DOI：
10.1023/a:1023033708204
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发表时间：
2003-04-01
影响因子：
3.8
通讯作者：
Sutherland, RL
中科院分区：
文献类型：
--
作者：
Ormandy, CJ;Musgrove, EA;Sutherland, RL
染色体位点11 q13在许多人类癌症中经常扩增，包括乳腺癌，其中高达15%携带这种染色体异常。最初认为11 q13扩增涉及跨越许多兆碱基的单个扩增子，但最近的数据已经确定了11 q13内的四个核心区域，它们可以独立扩增或以不同的组合一起扩增。尽管该区域含有几个已知或疑似致癌潜力的基因，但扩增子的复杂结构和11 q13基因丰富的事实使得明确鉴定有助于乳腺癌发生和进展的特定基因成为一个困难和持续的过程。到目前为止，CCND 1，编码细胞周期调控基因细胞周期蛋白D1，和EMS 1，编码丝状肌动蛋白结合蛋白和c-Src底物corneum，是有利的候选人负责出现的四个扩增核心。
Chromosome locus 11q13 is frequently amplified in a number of human cancers including carcinoma of the breast where up to 15% carry this chromosomal abnormality. Originally 11q13 amplification was thought to involve a single amplicon spanning many megabases, but more recent data have identified four core regions within 11q13 that can be amplified independently or together in different combinations. Although the region harbors several genes with known or suspected oncogenic potential, the complex structure of the amplicons and the fact that 11q13 is gene-rich have made definitive identification of specific genes that contribute to the genesis and progression of breast cancer a difficult and continuing process. To date CCND1, encoding the cell cycle regulatory gene cyclin D1, and EMS1, encoding the filamentous actin binding protein and c-Src substrate cortactin, are the favored candidates responsible for the emergence of two of the four amplification cores.