Matrix metalloproteinase degradation of extracellular matrix: biological consequences
Matrix metalloproteinase degradation of extracellular matrix: biological consequences
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DOI：
10.1016/s0955-0674(98)80035-5
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发表时间：
1998-10-01
影响因子：
7.5
通讯作者：
Shapiro, SD
中科院分区：
文献类型：
--
作者：
Shapiro, SD
靶向诱变使研究人员能够在哺乳动物中进行受控实验，并确定单个蛋白质对生理和病理过程的贡献。最近的经验教训，从基质金属蛋白酶基因靶向小鼠和其他在体内的观察给予了新的生命，旧的概念，关于细胞外基质蛋白的蛋白水解片段的作用，在调节细胞生物学中的各种关键过程。
Targeted mutagenesis has allowed investigators to perform controlled experiments in mammals and determine the contribution of individual proteins to physiologic and pathologic processes. Recent lessons learned from matrix metalloproteinase gene targeted mice and other in vivo observations have given new life to old concepts regarding the role of proteolytic fragments of extracellular matrix proteins in regulating a variety of critical processes in cell biology.