DOSE-VOLUME HISTOGRAMS
DOSE-VOLUME HISTOGRAMS
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DOI：
10.1016/0360-3016(91)90168-4
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发表时间：
1991-05-15
影响因子：
7
通讯作者：
URIE, M
中科院分区：
文献类型：
--
作者：
DRZYMALA, RE;MOHAN, R;URIE, M
累积剂量-体积频率分布的曲线图，通常称为剂量-体积直方图（DVH），以图形方式总结了患者的感兴趣体积内的模拟辐射分布，其将由所提出的辐射治疗计划产生。 DVH显示出作为比较针对特定患者的竞争治疗计划的工具的前景，其通过清楚地呈现靶体积中的剂量均匀性以及邻近正常器官或组织中的任何热点。 然而，由于所考虑的体积中的位置信息的损失，它不应该是计划评估的唯一标准。 DVH还可以用作输入数据来估计肿瘤控制概率（TCP）和正常组织并发症概率（NTCP）。 TCP和NTCP计算对DVH形状的微小变化的敏感性表明需要一种精确的方法来计算DVH。 我们提出了一个讨论的方法来生成和绘制的DVH，一些警告，限制其使用和一般经验的四家医院使用DVH。
A plot of a cumulative dose-volume frequency distribution, commonly known as a dose-volume histogram (DVH), graphically summarizes the simulated radiation distribution within a volume of interest of a patient which would result from a proposed radiation treatment plan. DVHs show promise as tools for comparing rival treatment plans for a specific patient by clearly presenting the uniformity of dose in the target volume and any hot spots in adjacent normal organs or tissues. However, because of the loss of positional information in the volume(s) under consideration, it should not be the sole criterion for plan evaluation. DVHs can also be used as input data to estimate tumor control probability (TCP) and normal tissue complication probability (NTCP). The sensitivity of TCP and NTCP calculations to small changes in the DVH shape points to the need for an accurate method for computing DVHs. We present a discussion of the methodology for generating and plotting the DVHs, some caveats, limitations on their use and the general experience of four hospitals using DVHs.