Influence of (S)-ketoprofen and fluoride on caries in rats.
Influence of (S)-ketoprofen and fluoride on caries in rats.
复制标题
(S)-酮洛芬和氟化物对大鼠龋齿的影响。
DOI：
10.1111/j.1601-0825.2000.tb00315.x
复制
发表时间：
2008
期刊：
影响因子：
3.8
通讯作者：
T. P. Jerussi
中科院分区：
文献类型：
--
作者：
W. Bowen;S. Pearson;T. P. Jerussi
OBJECTIVE
Non-steroidal anti-inflammatory agents (e.g., ketoprofen) used topically appear to be effective in reducing bone loss in the ligature model of periodontitis. Ketoprofen, in common with some food preservatives, e.g., benzoate and sorbate, is a weak acid. Fluoride, too, may behave as a weak acid and, similar to the other agents, may exert antibacterial effects. The purpose of the present study was to determine whether a combination of (S)-ketoprofen, an enantiomer of ketoprofen, alone or in combination with fluoride, would suppress Streptococcus sobrinus populations and reduce the incidence of dental caries in rats.
MATERIALS AND METHODS
Toothpastes containing ketoprofen and/or monofluorophosphate were applied to the teeth of six groups of 20 rats twice daily for 5 weeks.
RESULTS
Fewest S. sobrinus were found in the group treated with a paste containing 3% (S)-ketoprofen + 0.1% F. This group also displayed the lowest incidence of smooth surface caries of all groups. Severity of sulcal surface caries was also lowest in this group.
CONCLUSIONS
Results from this study show that the (S) enantiomer of ketoprofen enhances the caries protective effect of fluoride. It is conceivable that this combination could be effective in combating the two most common maladies of the mouth; periodontal disease and dental caries.
影响因子：
2.8
作者：
BELLI, WA;BUCKLEY, DH;MARQUIS, RE
通讯作者：
MARQUIS, RE