Comparative Expression of PEDF and VEGF in Human Epidermal Keratinocytes and Dermal Fibroblasts: from Normal Skin to Psoriasis
Comparative Expression of PEDF and VEGF in Human Epidermal Keratinocytes and Dermal Fibroblasts: from Normal Skin to Psoriasis
复制标题
PEDF 和 VEGF 在人表皮角质形成细胞和真皮成纤维细胞中的比较表达：从正常皮肤到银屑病
作者：
Bing-Xi Yan;Yu-Xin Zheng;Wei Li;Jia-Qi Chen;Jiong Zhou;Sui-Qing Cai;Min Zheng;Xiao-Yong Man
血管内皮生长因子（VEGF）和色素上皮衍生因子（PEDF）在正常和病理条件下保持血管生成激活和抑制的平衡。在这项研究中，我们研究了VEGF和PEDF在正常和银屑病皮肤的角质形成细胞和成纤维细胞中的表达，以评估它们在银屑病发展中的潜在作用和相互作用。VEGF和PEDF在正常皮肤和银屑病患者皮肤以及体外培养的角质形成细胞和成纤维细胞中均有表达，银屑病患者皮肤的角质形成细胞和成纤维细胞中VEGF和PEDF的表达较正常皮肤的角质形成细胞和成纤维细胞明显增加。我们的研究结果表明，PEDF作为一个多能性的因素，在皮肤和PEDF和VEGF的失衡可能是负责从正常皮肤银屑病的转化。
Vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have been shown to keep angiogenesis activation and inhibition in balance in normal and pathological conditions. In this study, we examined the expression of VEGF and PEDF in keratinocytes and fibroblasts from normal and psoriatic skin to evaluate their potential roles and interactions in the development of psoriasis. The expression of VEGF and PEDF was detected in normal and psoriatic skin ex vivo and in co-cultured keratinocytes and fibroblasts in vitro, and increased in keratinocytes and fibroblasts from psoriatic skin compared with those cells from normal skin. Our results suggest that PEDF act as a multipotent factor in the skin and the imbalance of PEDF and VEGF may be responsible for the transformation from normal skin to psoriasis.