Constipation is not associated with diverticular disease - Analysis of 976 patients
Constipation is not associated with diverticular disease - Analysis of 976 patients
复制标题
DOI：
10.1016/j.ijsu.2015.04.045
复制
发表时间：
2015-07-01
影响因子：
15.3
通讯作者：
Riss, Stefan
中科院分区：
文献类型：
--
作者：
Braunschmid, Tamara;Stift, Anton;Riss, Stefan
背景资料：在有争议的数据在文献中，本研究的目的是评估结肠憩室疾病，便秘和quality of life.Design之间的潜在关联：我们前瞻性地招募了976例连续患者，谁参加了全国范围内的大肠癌筛查计划在2008年和2009年之间的四个医疗中心。所有患者均接受完整的结肠镜检查并完成标准化问卷调查。通过经验证的Wexner便秘评分评估便秘的严重程度。结果：中位年龄为62岁（范围22-90岁），男女比例为1：1。在290名参与者（30%）中发现了结肠憩室病。年龄、体重指数和糖尿病与憩室病的存在显著相关（p < 0.0001，p = 0.0007和p = 0.0178）。憩室病患者的中位便秘评分为3（范围0-18），与无憩室患者相当（p = 0.1073）。SF-12的身体成分汇总在憩室病患者中显著降低（p = 0.0038）。结论：这项基于大规模人群的研究显示结肠憩室病和便秘之间没有关联。值得注意的是，憩室疾病的存在显著影响生活质量。(C)2015年出版集团有限公司。由爱思唯尔有限公司出版。保留所有权利。
Background: In the light of controversial data in the literature, the present study was designed to evaluate potential associations between colonic diverticular disease, constipation and quality of life.Design: We prospectively enrolled 976 consecutive patients, who participated in the nationwide colorectal cancer screening program in four medical centers between 2008 and 2009. All patients underwent full colonoscopy and completed a standardized questionnaire. The severity of constipation was assessed by the validated Wexner constipation score. Quality of Life (QOL) was evaluated by the SF-12 health score.Results: The median age was 62 years (range 22-90) and the male to female ratio was 1:1. Colonic diverticular disease was found in 290 participants (30%). Age, body mass index and diabetes mellitus were significantly associated with the presence of diverticular disease (p < 0.0001, p = 0.0007 and p = 0.0178).The median constipation score in patients with diverticular disease was 3 (range 0-18), and comparable to patients without diverticula (p = 0.1073). The physical component summary of the SF-12 was significantly reduced in patients with diverticular disease (p = 0.0038).Conclusion: This large population based study revealed no association between colonic diverticular disease and constipation. Notably, the presence of diverticular disease significantly impacts quality of life. (C) 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.