Does feeding tube placement predict for long-term swallowing disability after radiotherapy for head and neck cancer?
Does feeding tube placement predict for long-term swallowing disability after radiotherapy for head and neck cancer?
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DOI：
10.1002/hed.10279
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发表时间：
2003-09-01
影响因子：
2.9
通讯作者：
Mendenhall, WM
中科院分区：
文献类型：
--
作者：
Al-Othman, MOF;Amdur, RJ;Mendenhall, WM
目的。评估饲管的使用。材料与方法。934例患者行放射治疗（FIT）。235例（25%）患者放置了饲管：急性毒性212例（22.5%），晚期效应18例（2%），两者均有5例（0.5%）。急性毒性的中位管依赖时间为3.8个月。多因素分析显示，FIT剂量越高（p < 0.0001）、辅助化疗（p = 0.0002）、年龄越大（p = 0.0002）、有无颈部疾病（p = 0.0045），急性毒性患者置管率越高。5年时，使用饲管的后期效应风险为2%。对于女性（p = 0.0293）、更高的FIT剂量（p = 0.0345）和原发部位，包括下咽和多个同步原发肿瘤（p = 0.0360），放置饲管的可能性更大。置管治疗晚期毒性与置管治疗急性毒性无关。长期依赖饲管的可能性较低，与急性效应的放置无关。(C) 2003 Wiley期刊有限公司
Purpose. To evaluate feeding tube use.Materials and Methods. Nine hundred thirty-four patients were treated with radiotherapy (FIT).Results. Feeding tubes were placed in 235 patients (25%): 212 patients (22.5%) for acute toxicity, 18 patients (2%) for late effects, and 5 patients (0.5%) for both. Median duration of tube dependence for acute toxicity was 3.8 months. Multivariate analysis revealed that feeding tube placement for acute toxicity was increased with higher FIT dose (p < .0001), adjuvant chemotherapy (p = .0002), advanced age (p = .0002), and the presence of neck disease (p = .0045). The risk of a feeding tube for late effects was 2% at 5 years. The likelihood of feeding tube placement for late effects was greater for women (p = .0293), higher FIT dose (p = .0345), and primary sites, including the hypopharynx and multiple synchronous primary tumors (p = .0360). Feeding tube placement for late effects was unrelated to tube placement for acute toxicity.Conclusion. Likelihood of long-term feeding tube dependence was low and unrelated to placement for acute effects. (C) 2003 Wiley Periodicals, Inc.