CHROMOGRANIN-A, CHROMOGRANIN-B, AND CHROMOGRANIN-C - WIDESPREAD CONSTITUENTS OF SECRETORY VESICLES
CHROMOGRANIN-A, CHROMOGRANIN-B, AND CHROMOGRANIN-C - WIDESPREAD CONSTITUENTS OF SECRETORY VESICLES
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DOI：
10.1111/j.1749-6632.1987.tb27189.x
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发表时间：
1987-04-24
影响因子：
5.2
通讯作者：
SCHOBER, M
中科院分区：
文献类型：
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作者：
FISCHERCOLBRIE, R;HAGN, C;SCHOBER, M
嗜铬粒蛋白是嗜铬粒蛋白的总称。“在过去的20年里，这些嗜铬粒蛋白已经被分析和表征得非常详细（综述见参考文献）。2-5），它们的物理化学性质和生物合成途径的建立，并在1986年首次获得了一个嗜铬粒蛋白的一级序列由Iacangelo等6尽管如此，这些特征蛋白的生理功能仍然是未知的。最初认为这些蛋白质与儿茶酚胺的储存复合物有关。然而，最近的研究表明，这些蛋白质在几个非肾上腺素能内分泌和神经组织中广泛分布，这一发现提出了质疑。在本文中，我们总结了最近的证据表明，嗜铬粒蛋白与神经肽和调节肽的相似性，这表明这些蛋白质可能有一个功能后，分泌到循环中。
The acidic soluble proteins of chromaf6n granules have been collectively named chromogranins.'During the last 20 years these chromogranins have been analyzed and characterized in great detail (for review see refs. 2-5), their physicochemical properties and biosynthetic pathways established, and in 1986 the primary sequence of one chromogranin was obtained for the first time by Iacangelo et aL6 Nonetheless, the physiological function of these characteristic proteins is still unknown. Originally it was thought that these proteins are involved in a storage complex with catecholamines. More recent studies demonstrating a widespread distribution of these proteins in several nonadrenergic endocrine and neuronal tissues have, however, called into question this finding. In this paper we summarize recent evidence demonstrating similarities of the chromogranins with neuropeptides and regulatory peptides which suggest that these proteins might have a function after secretion into circulation.