EFFECT OF ENVIRONMENTAL MOLDS ON RISK OF DEATH FROM ASTHMA DURING THE POLLEN SEASON
EFFECT OF ENVIRONMENTAL MOLDS ON RISK OF DEATH FROM ASTHMA DURING THE POLLEN SEASON
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DOI：
10.1016/s0091-6749(95)70095-1
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发表时间：
1995-05-01
影响因子：
14.2
通讯作者：
RAMEKRISHNAN, V
中科院分区：
文献类型：
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作者：
TARGONSKI, PV;PERSKY, VW;RAMEKRISHNAN, V
目的：许多研究已经注意到环境空气过敏原水平与哮喘恶化的关系。本研究旨在检查芝加哥空气过敏原水平与哮喘相关死亡率的关系。方法：对1985 ~ 1989年芝加哥5 ~ 34岁人群中环境空气过敏原水平与哮喘死亡的关系进行了研究。采用Logistic回归分析比较环境中树木、草或豚草花粉和霉菌孢子水平导致哮喘死亡的概率。结果：哮喘相关死亡发生天数的平均霉菌孢子水平显著高于未发生死亡的天数（z = 2.80, p < 0.005），而树木、草或豚草花粉水平不显著高于未发生死亡的天数（p < 0.005）。在霉菌孢子计数为每立方米1000孢子或更高的日子里，哮喘死亡的几率是霉菌孢子计数低于每立方米1000孢子的日子的2.16倍（95%可信区间= 1.31,3.56,p = 0.003）。在多变量logistic回归中，霉菌孢子计数作为一个连续变量测量，并控制花粉，与霉菌孢子水平的关联仍然显著。每天霉菌孢子水平每增加1000个孢子/立方米，哮喘相关死亡的几率就增加1.2倍（95%置信区间= 1.07-1.34）。结论：虽然哮喘引起的死亡还涉及个人、社会和医疗获取因素，但这些数据表明，暴露于环境霉菌可能在哮喘相关死亡中发挥作用，应在预防策略中加以考虑。
Objective: Many studies have noted an association of ambient aeroallergen levels with exacerbation of asthma. This study was undertaken to examine the relationship of aeroallergen levels with asthma-related mortality in Chicago.Methods: The association of environmental aeroallergen levels with death caused by asthma among 5- to 34-year-olds in Chicago was examined for the period of 1985 through 1989. Logistic regression analysis was used to compare the probability of a death caused by asthma occurring on the basis of environmental tree, grass, or ragweed pollen and mold spore levels.Results: Mean mold spore levels but not tree, grass, or ragweed pollen levels were significantly highs for days on which asthma-related death occurred than for days on which no deaths occurred (z = 2.80, p < 0.005). The odds of a death caused by asthma occurring on days with mold spore counts of 1000 spores per cubic meter or greater was 2.16 times higher (95% confidence interval = 1.31, 3.56, p = 0.003) than on days on which mold spore counts were less than 1000 spores per cubic meter The association with mold spore levels remained significant on multivariate logistic regression with mold spore counts measured as a continuous variable and controlling for pollens, with the odds of an asthma-related death occurring being 1.2 times higher (95% confidence interval = 1.07-1.34) for every increase of 1000 spores per cubic meter in daily mold spore levels.Conclusion: Although death caused by asthma also involves personal, social, and medical access factors, these data suggest that exposure to environmental molds may play a role in asthma-related mortality and should be considered in prevention strategies.