The dilute-lethal (d(l)) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice
The dilute-lethal (d(l)) gene attacks a Ca2+ store in the dendritic spine of Purkinje cells in mice
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DOI：
10.1016/s0304-3940(96)12967-0
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发表时间：
1996-09-13
影响因子：
2.5
通讯作者：
Yamamura, H
中科院分区：
文献类型：
--
作者：
Takagishi, Y;Oda, S;Yamamura, H
用抗肌醇1，4，5-三磷酸受体抗体免疫组化和电子显微镜观察发现，稀释致死（d（l））小鼠小脑浦肯野细胞树突棘内缺少滑面内质网（SER）。由于已经提出脊柱中的SER作为细胞内Ca 2+储存对突触调节起关键作用（综述参见[米勒，R. J.，青蛙神经生物学，37（1991）255-285; Simpson，P.B.，Challiss，R.A.J.和Nahorski，S.R.，神经科学趋势，18（1995）299-306]），一种神经学缺陷，其特征在于在具有纯合性状的稀释致死小鼠中具有角弓反张和共济失调的阵挛性惊厥，这可能归因于浦肯野细胞的树突棘中缺乏SER。
The absence of smooth endoplasmic reticulum (SER) in the dendritic spine of Purkinje cells was found in dilute-lethal (d(l)) mouse cerebella as detected by immunohistochemistry using anti-inositol 1,4,5-triphosphate receptor antibody and electron microscopy. Since SER in the spine has been suggested to play a crucial role for synaptic regulation as an intracellular Ca2+ store (for reviews, see [Miller, R.J., Frog. Neurobiol., 37 (1991) 255-285; Simpson, P.B., Challiss, R.A.J. and Nahorski, S.R., Trends Neurosci., 18 (1995) 299-306]), a neurological defect, characterized by clonic convulsions with opisthotonus and ataxia, in the dilute-lethal mouse with homozygous trait may be attributable to the absence of SER in the dendritic spine of Purkinje cells.