A common system for the comprehension and production of narrative speech
A common system for the comprehension and production of narrative speech
复制标题
DOI：
10.1523/jneurosci.5257-06.2007
复制
发表时间：
2007-10-24
影响因子：
5.3
通讯作者：
Wise, Richard J. S.
中科院分区：
文献类型：
--
作者：
Awad, Malaka;Warren, Jane E.;Wise, Richard J. S.
人类花费大量时间在共享的一般和个人语义知识的背景下交换记忆。我们的假设是，在正常受试者的功能成像将证明收敛的言语理解和生产的高阶异模态和amodal皮质区牵连的陈述性记忆功能。活动独立于言语阶段（即理解和生产）是最明显的左，右外侧前颞叶皮层。在角回腹侧的后皮质也观察到显著的活动。左右海马和相邻的下颞叶皮层在言语理解过程中是活跃的，与记忆编码的叙事信息相兼容，但活动显着减少与言语产生相关的外显记忆检索。因此，尽管临床研究表明海马的功能对于记忆的提取和编码都是必要的，但前者似乎依赖于更少的净突触活动。与此相反，后压/后扣带皮层和海马旁区，这是密切相关的解剖海马，同样活跃在言语理解和生产。结果表明，为什么在没有语言形式处理障碍的情况下，通常只在双侧，特别是前部颞叶破坏后观察到严重和持续的无法理解和产生有意义的语音，并强调了压后/后扣带皮层的重要性，该区域已知在阿尔茨海默病早期受到影响，在交流过程中记忆的处理过程中。
Humans devote much time to the exchange of memories within the context of shared general and personal semantic knowledge. Our hypothesis was that functional imaging in normal subjects would demonstrate the convergence of speech comprehension and production on high-order heteromodal and amodal cortical areas implicated in declarative memory functions. Activity independent of speech phase ( that is, comprehension and production) was most evident in the left and right lateral anterior temporal cortex. Significant activity was also observed in the posterior cortex, ventral to the angular gyri. The left and right hippocampus and adjacent inferior temporal cortex were active during speech comprehension, compatible with mnemonic encoding of narrative information, but activity was significantly less during the overt memory retrieval associated with speech production. Therefore, although clinical studies suggest that hippocampal function is necessary for the retrieval as well as the encoding of memories, the former appears to depend on much less net synaptic activity. In contrast, the retrosplenial/posterior cingulate cortex and the parahippocampal area, which are closely associated anatomically with the hippocampus, were equally active during both speech comprehension and production. The results demonstrate why a severe and persistent inability both to understand and produce meaningful speech in the absence of an impairment to process linguistic forms is usually only observed after bilateral, and particularly anterior, destruction of the temporal lobes, and emphasize the importance of retrosplenial/posterior cingulate cortex, an area known to be affected early in the course of Alzheimer's disease, in the processing of memories during communication.