Coordinated activities of retrosplenial ensembles during resting-state encode spatial landmarks
Coordinated activities of retrosplenial ensembles during resting-state encode spatial landmarks
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DOI：
10.1098/rstb.2019.0228
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发表时间：
2020-05-25
影响因子：
6.3
通讯作者：
McNaughton, Bruce L.
中科院分区：
文献类型：
--
作者：
Chang, HaoRan;Esteves, Ingrid M.;McNaughton, Bruce L.
大脑可能会使用离线时间来巩固最近的记忆。一种假设认为，海马输出为每个记忆提供了一个独特的全局链接或“索引”代码，并且该代码与每个记忆的本地编码属性相关联地存储在皮层中。激活的索引代码被假设为唤起协调的记忆痕迹再激活，从而促进巩固。压后皮质（RSC）是海马外流的主要接受者，我们已经描述了神经元的群体有稀疏和正交的编码特征，类似于海马的“地方”细胞，其表达依赖于一个完整的海马。使用双光子钙离子成像，我们记录了在一个熟悉的线性跑步机轨道上积极运行之前和之后的不动期间的RSC中的神经元的集合。同步爆发的不同群体的神经元发生在休息之前和之后运行。在第二个休息时期，这些模式与触觉地标和奖励的位置有关。我们的研究结果补充了关于RSC功能的既定观点，表明该结构涉及在休息时处理地标信息。本文是Theo Murphy会议问题“记忆重新激活：重放过去，现在和未来的事件”的一部分。
The brain likely uses offline periods to consolidate recent memories. One hypothesis holds that the hippocampal output provides a unique, global linking or 'index' code for each memory, and that this code is stored in the cortex in association with locally encoded attributes of each memory. Activation of the index code is hypothesized to evoke coordinated memory trace reactivation thus facilitating consolidation. Retrosplenial cortex (RSC) is a major recipient of hippocampal outflow and we have described populations of neurons there with sparse and orthogonal coding characteristics that resemble hippocampal 'place' cells, and whose expression depends on an intact hippocampus. Using two-photon Ca2+ imaging, we recorded ensembles of neurons in the RSC during periods of immobility before and after active running on a familiar linear treadmill track. Synchronous bursting of distinct groups of neurons occurred during rest both prior to and after running. In the second rest epoch, these patterns were associated with the locations of tactile landmarks and reward. Complementing established views on the functions of the RSC, our findings indicate that the structure is involved with processing landmark information during rest.This article is part of the Theo Murphy meeting issue 'Memory reactivation: replaying events past, present and future'.