Prostaglandins during pregnancy and the perinatal period.
Prostaglandins during pregnancy and the perinatal period.
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怀孕期间和围产期的前列腺素。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
M. Mitchell
中科院分区：
文献类型：
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作者：
M. Mitchell
服用前列腺素(PGs)E-2和F-2会在怀孕的任何阶段引起人类子宫收缩。这些化合物用于足月引产和流产现在很普遍，而且有很好的记录(Bygdeman，1980)。最近，人们发现PGs可以影响宫颈成熟，这一特性正得到良好的临床应用(Bygdeman，1980)。也有证据表明，前列腺素合成酶抑制剂(PGSI)可以抑制怀孕和未怀孕妇女的子宫收缩(Wiqvist，1979)。不幸的是，PGSI作为一种治疗早产的方法，由于药物经胎盘通过后在子宫内关闭动脉导管的不良副作用(现已得到充分证实)，导致新生儿原发性肺动脉高压，大大降低了其治疗潜力。这一现象的发生与使用实验动物的研究结果一致，有力地表明PGE在子宫中维持动脉导管的通畅(Cocani，Olley&Bodach，1976)。
Administration of prostaglandins (PGs) E-2 and F-2{alpha} will provoke contractions of the human uterus at any stage of pregnancy. The use of these compounds for the induction both of labour at term and of abortion is now widespread and well documented (Bygdeman, 1980). Recently, it has been found that PGs can effect cervical ripening and this property is being put to good clinical advantage (Bygdeman, 1980). There is evidence also that prostaglandin synthetase inhibitors (PGSI) can inhibit uterine contractions in pregnant and non-pregnant women (Wiqvist, 1979). Unfortunately, the therapeutic potential of PGSI, as a treatment for pre-term labour, is drastically reduced by the adverse side effect (now well documented) of closure of the ductus arteriosus in utero, after transplacental passage of the drug, leading to primary pulmonary hypertension of the newborn. The occurrence of this phenomenon is consistent with results from studies using experimental animals, strongly suggesting that PGE maintains the patency of the ductus arteriosus in utero (Coceani, Olley & Bodach, 1976).