Adiponectin in umbilical cord blood is inversely related to low-density lipoprotein cholesterol but not ethnicity
Adiponectin in umbilical cord blood is inversely related to low-density lipoprotein cholesterol but not ethnicity
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DOI：
10.1210/jc.2005-2714
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发表时间：
2006-06-01
影响因子：
5.8
通讯作者：
Durrington, Paul N.
中科院分区：
文献类型：
--
作者：
Bansal, Narinder;Charlton-Menys, Valentine;Durrington, Paul N.
背景：脂联素是公认的成人心血管疾病的保护性风险标记物，并与最佳的血脂水平相关。脂联素在出生时的作用还不清楚，它与新生儿血脂谱的关系也是未知的。由于低脂联素及其相关的低高密度脂蛋白胆固醇(HDLC)的种族差异被归因于低脂联素及其相关的低高密度脂蛋白胆固醇(HDLC)，出生时的调查可能有助于确定这些危险模式的病因。目的：我们的目标是调查两个民族脐带血中新生儿脂联素与出生时血脂的关系。设计、地点和对象：74名南亚裔和欧洲白人血统的健康母亲和她们的新生儿在这项横断面研究中进行了研究。主要观察指标：血清脂联素、总胆固醇、高密度脂蛋白-C、结果：脐带脂联素与脐血低密度脂蛋白胆固醇呈显著负相关(r=-0.32；P=0.005)，但不是高密度脂蛋白胆固醇。在多元回归分析中，脐血低密度脂蛋白与脐带脂联素的相关性最显著(β=-0.13；P=0.001)。我们没有发现脐带脂联素或血脂有任何明显的种族差异，除了甘油三酯在南亚新生儿中显著降低(P<；0.05)。结论：这是首次报道出生时脐带脂联素与低密度脂蛋白呈负相关。与成人研究相比，我们发现脐带血中的脂联素和高密度脂蛋白胆固醇之间没有显著的关联。我们的结果和成人研究中观察到的脂联素和高密度脂蛋白胆固醇之间的强烈独立联系表明，脂联素在脂质代谢中起着作用。脂联素的种族差异可能在出生后出现。
Context: Adiponectin is a recognized protective risk marker for cardiovascular disease in adults and is associated with an optimal lipid profile. The role of adiponectin at birth is not well understood, and its relationship with the neonatal lipid profile is unknown. Because ethnic disparities in cardiovascular risk have been attributed to low adiponectin and its associated low high-density lipoprotein cholesterol (HDL-C), investigation at birth may help determine the etiology of these risk patterns.Objective: Our objective was to investigate the relationship between neonatal adiponectin and lipid profile at birth in two ethnic groups in cord blood.Design, Setting, and Participants: Seventy-four healthy mothers and their newborns of South Asian and White European origin were studied in this cross-sectional study at St. Mary's Hospital, Manchester, United Kingdom.Main Outcome Measures: Serum adiponectin, total cholesterol, HDL-C, low-density lipoprotein cholesterol (LDL-C), and triglyceride levels were measured in umbilical venous blood at birth and in maternal blood collected at 28 wk gestation.Results: Cord adiponectin was significantly inversely associated with cord LDL-C (r=-0.32; P=0.005) but not HDL-C. In a multiple regression analysis, cord LDL-C remained the most significant association of cord adiponectin (beta=-0.13; P=0.001). We did not find any significant ethnic differences in cord adiponectin or lipids with the exception of triglycerides, which were significantly lower in South Asian newborns (P < 0.05).Conclusion: This is the first report of an inverse relationship between cord adiponectin and LDL-C at birth. In contrast to adult studies, we found no significant association between adiponectin and HDL-C in cord blood. Our results and the strong independent association between adiponectin and HDL-C observed in adult studies suggest a role for adiponectin in lipid metabolism. Ethnic differences in adiponectin may arise after birth.