Comparisons of carcinogenicities of nickel compounds in rats.
Comparisons of carcinogenicities of nickel compounds in rats.
复制标题
镍化合物对大鼠致癌性的比较。
DOI：
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发表时间：
1976
期刊：
影响因子：
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通讯作者：
R. Maenza
中科院分区：
文献类型：
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作者：
F. Sunderman;R. Maenza
这项研究表明，在一次肌肉注射4种不溶镍粉后2年内，Fischer大鼠的肉瘤发生率有显著差异：非晶态一硫化镍(NIS)、亚硫化镍(AlphaNi3S2)、部分转化的镍铁硫化物冰铜和金属镍。将这些粉末(平均粒径小于2微米)加入青霉素混悬液中，每个粉末按2个剂量进行测试。虽然αNi3S2具有高度致癌性，但无定形NiS不会诱发任何肿瘤。部分转化的镍铁硫化物冰铜的致癌活性低于αNi3S2，但大于镍粉。肌注青霉素或铁粉的两组对照组大鼠注射部位均未见肉瘤。观察到αNi3S2和无定形NiS致癌能力的差异可能为阐明镍致癌的分子机制提供实验方法。
This study demonstrates marked differences in the incidences of sarcomas in Fischer rats within 2 years after a single im injection of 4 insoluble nickel-containing powders: amorphous nickel monosulfide (NiS), nickel subsulfide (alphaNi3S2), partially converted nickel-iron sulfide matte, and metallic nickel. The powders (less than 2 um median particle diameters) were administered in penicillin suspension, and each powder was tested at 2 dosages. Whereas alphaNi3S2 was highly carcinogenic, amorphous NiS did not induce any tumors. The carcinogenic potency of partially converted nickel-iron sulfide matte was less than alphaNi3S2 but greater than Ni powder. No sarcomas occurred at the injection site in two groups of control rats that received im injections of penicillin or Fe powder. The observed differences in carcinogenic potencies of alphaNi3S2 and amorphous NiS may provide an experimental approach to elucidate the molecular mechanisms of nickel carcinogenesis.