Cost-effectiveness of Private Umbilical Cord Blood Banking
Cost-effectiveness of Private Umbilical Cord Blood Banking
复制标题
DOI：
10.1097/aog.0b013e3181b8fc0d
复制
发表时间：
2009-10-01
影响因子：
7.2
通讯作者：
Cheng, Yvonne W.
中科院分区：
文献类型：
--
作者：
Kaimal, Anjali J.;Smith, Catherine C.;Cheng, Yvonne W.
目的：方法：设计了一个决策分析模型，比较了私营脐带血库与非脐带血库的成本效益。基线假设包括脐带血库和储存20年的费用为3，620美元，需要自体干细胞移植的机会为0.04%，兄弟姐妹需要异基因干细胞移植的机会为0.07%，如果兄弟姐妹使用库中的脐带血，移植物抗宿主病的风险降低50%。私人脐带血库不具有成本效益，因为它每获得一个生命年就要额外花费1，374，246美元。在敏感性分析中，如果脐带血银行的成本低于262美元或一个孩子需要干细胞移植的可能性大于1在110，私人脐带血银行成为cost-effectiveness.CONCLUSION：目前，私人脐带血银行是具有成本效益的只有一个非常高的可能性需要干细胞移植的儿童。考虑私人血库的患者应被告知一个单元将用于儿童或其他家庭成员的可能性很小。（妇产科2009;114：848-55）
OBJECTIVE: To investigate the cost-effectiveness of private umbilical cord blood banking.METHODS: A decision-analytic model was designed comparing private umbilical cord blood banking with no umbilical cord blood banking. Baseline assumptions included a cost of $3,620 for umbilical cord blood banking and storage for 20 years, a 0.04% chance of requiring an autologous stem cell transplant, a 0.07% chance of a sibling requiring an allogenic stem cell transplant, and a 50% reduction in risk of graft-versus-host disease if a sibling uses banked umbilical cord blood.RESULTS: Private cord blood banking is not cost-effective because it cost an additional $1,374,246 per life-year gained. In sensitivity analysis, if the cost of umbilical cord blood banking is less than $262 or the likelihood of a child needing a stem cell transplant is greater than 1 in 110, private umbilical cord blood banking becomes cost-effective.CONCLUSION: Currently, private umbilical cord blood banking is cost-effective only for children with a very high likelihood of needing a stem cell transplant. Patients considering private blood banking should be informed of the remote likelihood that a unit will be used for a child or another family member. (Obstet Gynecol 2009;114:848-55)