Risk factors for functional limitations in patients with long-standing ankylosing spondylitis.
Risk factors for functional limitations in patients with long-standing ankylosing spondylitis.
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DOI：
10.1002/art.21444
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发表时间：
2005-10
影响因子：
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通讯作者：
M. Ward;M. Weisman;John C. Davis;J. Reveille
中科院分区：
文献类型：
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作者：
M. Ward;M. Weisman;John C. Davis;J. Reveille
目的 确定病程至少 20 年的强直性脊柱炎 (AS) 患者功能受限的危险因素。方法 患有 AS ≥20 年的患者被纳入 AS 预后前瞻性研究的横断面部分。所有患者均进行了临床评估并完成了有关功能限制和潜在危险因素的调查问卷。使用巴斯强直性脊柱炎功能指数（BASFI；评分范围 0-100，分数越高表示限制越多）和脊柱关节病健康评估问卷 (HAQS) 评估功能限制。危险因素包括人口特征、AS持续时间、吸烟状况、合并症的数量、青少年和二十多岁的娱乐活动回忆水平、一生中的职业体力活动（评级1=少量、2=中度、3=重度，并按每项工作的年数加权）以及一级亲属的AS病史。结果 326 名患者（74% 为男性）的平均 +/- SD 年龄为 55.0 +/- 10.7 岁，平均 AS 症状持续时间为 31.7 +/- 10.2 年，平均 BASFI 评分为 40.7 +/- 25.6。 BASFI 分数随着终生职业体力活动的增加而增加（r = 0.31；P /=20 年），在那些从事过体力要求较高的工作、患有更多合并症和吸烟者中得分更高，而在受教育程度较高和有 AS 家族史的人中得分则不太严重。
OBJECTIVE To identify risk factors for functional limitations in patients with ankylosing spondylitis (AS) of at least 20 years' duration. METHODS Patients with AS for > or =20 years were enrolled in the cross-sectional component of the Prospective Study of Outcomes in AS. All patients had clinical evaluations and completed questionnaires on functional limitations and potential risk factors. Functional limitations were assessed using the Bath Ankylosing Spondylitis Functional Index (BASFI; score range 0-100, higher scores indicate more limitations) and the Health Assessment Questionnaire for the Spondylarthropathies (HAQS). Risk factors included demographic characteristics, duration of AS, smoking status, number of comorbid medical conditions, recalled level of recreational activity in teens and twenties, occupational physical activity throughout life (rated 1 = little, 2 = moderate, 3 = heavy, and weighted by the number of years in each job), and history of AS in a first-degree relative. RESULTS The 326 patients (74% men) had a mean +/- SD age of 55.0 +/- 10.7 years, a mean duration of AS symptoms of 31.7 +/- 10.2 years, and a mean BASFI score of 40.7 +/- 25.6. BASFI scores increased with higher lifetime occupational physical activity (r = 0.31; P /=20 years are greater among those with a history of more physically demanding jobs, more comorbid conditions, and among smokers, and are less severe among those with higher levels of education and a family history of AS.