Physical activity and risk of colon and rectal cancers:: The European Prospective Investigation into Cancer and Nutrition
Physical activity and risk of colon and rectal cancers:: The European Prospective Investigation into Cancer and Nutrition
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DOI：
10.1158/1055-9965.epi-06-0595
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发表时间：
2006-12-01
影响因子：
3.8
通讯作者：
Riboli, Elio
中科院分区：
文献类型：
--
作者：
Friedenreich, Christine;Norat, Teresa;Riboli, Elio
我们调查了身体活动在结肠癌和直肠癌病因学中的作用的几个方面，这些方面在欧洲营养与癌症前瞻性调查中仍然不清楚。该队列的413，044名男性和女性在平均6.4年的随访期间诊断出1，094例结肠癌和599例直肠癌。我们分析了职业、家庭和娱乐活动的基线数据，以检查活动类型、肿瘤亚部位、体重指数（BMI）和能量摄入的相关性。与非活动参与者相比，最活跃参与者中结肠癌的多变量风险比为0.78 [95%置信区间（95%CI），0.59-1.03]，有剂量反应效应的证据（P趋势= 0.04）。对于右侧结肠肿瘤，活动性最高四分位数的风险为0.65（95% CI，0.43-1.00），有线性趋势的证据（P趋势=0.004）。与不活动者相比，BMI低于25的活动参与者患结肠癌的风险为0.63（95%CI，0.39-1.01）。最后，在右侧结肠癌中观察到BMI和活动之间的相互作用（P-相互作用=0.03）;在BMI低于25的中度活动和活动参与者中，与BMI > 30的非活动参与者相比，发现风险为0.38（95%CI，0.21-0.68）。对于任何亚组分析或考虑的相互作用，任何类型的体力活动均未观察到直肠癌风险的可比降低。我们发现，体力活动降低了结肠癌的风险，特别是对于右侧肿瘤和瘦参与者，但不是直肠癌。
We investigated several aspects of the role of physical activity in colon and rectal cancer etiology that remain unclear in the European Prospective Investigation into Nutrition and Cancer. This cohort of 413,044 men and women had 1,094 cases of colon and 599 cases of rectal cancer diagnosed during an average of 6.4 years of follow-up. We analyzed baseline data on occupational, household, and recreational activity to examine associations by type of activity, tumor subsite, body mass index (BMI), and energy intake. The multivariate hazard ratio for colon cancer was 0.78 [95% confidence interval (95% CI), 0.59-1.03] among the most active participants when compared with the inactive, with evidence of a dose-response effect (P-trend = 0.04). For right-sided colon tumors, the risk was 0.65 (95% CI, 0.43-1.00) in the highest quartile of activity with evidence of a linear trend (P-trend=0.004). Active participants with a BMI under 25 had a risk of 0.63 (95% CI, 0.39-1.01) for colon cancer compared with the inactive. Finally, an interaction between BMI and activity (P-interaction=0.03) was observed for right-sided colon cancers; among moderately active and active participants with a BMI under 25, a risk of 0.38 (95% CI, 0.21-0.68) was found as compared with inactive participants with BMI > 30. No comparable decreased risks were observed for rectal cancer for any type of physical activity for any subgroup analyses or interactions considered. We found that physical activity reduced colon cancer risk, specifically for right-sided tumors and for lean participants, but not rectal cancer.