The environment and schizophrenia
The environment and schizophrenia
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DOI：
10.1038/nature09563
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发表时间：
2010-11-11
期刊：
影响因子：
64.8
通讯作者：
Rutten, Bart P. F.
中科院分区：
文献类型：
--
作者：
van Os, Jim;Kenis, Gunter;Rutten, Bart P. F.
精神病综合症可以理解为对社会环境的适应障碍。虽然遗传性经常被强调，但发病与环境因素有关，如早期生活中的逆境、在城市环境中长大、少数群体的地位和大麻的使用，这表明暴露在敏感时期可能会对发育中的“社会”大脑产生影响。因此，遗传力作为遗传影响的一个指标，除非从与社会影响相互作用的角度来看，否则解释能力可能有限。需要进行纵向研究，以揭示基因-环境的相互作用，以确定普通人群中的脆弱性表达如何可能导致更严重的精神病理。
Psychotic syndromes can be understood as disorders of adaptation to social context. Although heritability is often emphasized, onset is associated with environmental factors such as early life adversity, growing up in an urban environment, minority group position and cannabis use, suggesting that exposure may have an impact on the developing 'social' brain during sensitive periods. Therefore heritability, as an index of genetic influence, may be of limited explanatory power unless viewed in the context of interaction with social effects. Longitudinal research is needed to uncover gene-environment interplay that determines how expression of vulnerability in the general population may give rise to more severe psychopathology.