Intermediate filaments are dynamic and motile elements of cellular architecture
Intermediate filaments are dynamic and motile elements of cellular architecture
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DOI：
10.1242/jcs.00936
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发表时间：
2004-01-15
影响因子：
4
通讯作者：
Goldman, RD
中科院分区：
文献类型：
--
作者：
Helfand, BT;Chang, L;Goldman, RD
最近的证据表明，中间丝（IF）是动态的，能动的细胞骨架的元素。对脊椎动物细胞库的研究推翻了长期以来的观点，即它们只是形成静态的“空间填充”细胞质网络。事实上，现在已知许多类型的IF参与一系列与其组装、拆卸和亚细胞组织密切相关的运动。这些能动性中的一些是固有的IF和其他人是由于与微管或肌动蛋白的微丝分子串扰。这种串扰在很大程度上是由分子马达介导的，包括传统的驱动蛋白和细胞质动力蛋白。这些马达负责将非丝状IF前体和短纤维高速递送到细胞质的特定区域，在那里它们组装成长IF。有趣的是，IF运动的模式和速度在不同的细胞类型中不同，甚至在同一细胞的不同区域内也不同。运动性的这些差异可能与它们与不同类型的分子马达和/或其他因子（如IF相关蛋白）的相互作用有关。
Recent evidence showing that intermediate filaments (IFs) are dynamic, motile elements of the cytoskeletal. repertoire of vertebrate cells has overturned the long-standing view that they simply form static 'space filling' cytoplasmic networks. In fact, many types of IF are now known to engage in a remarkable array of movements that are closely associated with their assembly, disassembly and subcellular organization. Some of these motile properties are intrinsic to IFs and others are attributable to molecular crosstalk with either microtubules or actin-containing microfilaments. This crosstalk is, to a large extent, mediated by molecular motors, including conventional kinesin and cytoplasmic dynein. These motors are responsible for the high-speed delivery of nonfilamentous IF precursors and short filaments to specific regions of the cytoplasm, where they assemble into long IFs. Interestingly, the patterns and speeds of IF movements vary in different cell types and even within different regions of the same cell. These differences in motility may be related to their interactions with different types of molecular motor and/or other factors, such as IF-associated proteins.