The TBP-like factor: an alternative transcription factor in Metazoa?
The TBP-like factor: an alternative transcription factor in Metazoa?
复制标题
DOI：
10.1016/s0968-0004(99)01436-x
复制
发表时间：
1999-09-01
影响因子：
13.8
通讯作者：
Tora, L
中科院分区：
文献类型：
--
作者：
Dantonel, JC;Wurtz, JM;Tora, L
蛋白质序列分析揭示了后生动物生物中的TATA结合蛋白（TBP）样因子（TLF）家族。对这些TLF的三维结构的建模表明，它们形成了不对称的鞍状结构，并且与TBP不同，TLF可能与经典TATA盒以外的DNA序列结合。因此，TLF的存在对TBP是后生动物中转录的通用调节因子的学说提出了挑战。
Protein sequence analysis has revealed a family of TATA-binding-protein (TBP)-like factors (TLFs) in metazoan organisms. Modelling of the three-dimensional structure of these TLFs suggests that they form an asymmetric saddle-like structure and that, unlike TBP, TLFs might bind to DNA sequences other than classical TATA boxes. Thus, the existence of TLFs presents a challenge to the doctrine that TBP is a universal regulator of transcription in metazoans.