Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin.
Synthesis and anticancer activity of novel amide derivatives of non-acetal deoxoartemisinin.
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DOI：
10.1016/j.bmcl.2009.09.093
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发表时间：
2009-11
影响因子：
2.7
通讯作者：
M. Jung;Namsoo Park;H. Moon;Yongnam Lee;W. Chung;Kwang-Kyun Park
中科院分区：
文献类型：
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作者：
M. Jung;Namsoo Park;H. Moon;Yongnam Lee;W. Chung;Kwang-Kyun Park
合成了新型的12位非缩醛脱氧青蒿素酰胺衍生物。一些衍生物对主要的人类癌细胞系具有有效的体外抗癌活性。根据小鼠基质胶塞测定，脱氧青蒿素酰胺三聚体具有有效的体内抗血管生成活性。
Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay.