Incident diabetes complications among women with type 1 diabetes based on parity.
Incident diabetes complications among women with type 1 diabetes based on parity.
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基于胎次的 1 型糖尿病女性糖尿病并发症发生率。
DOI：
10.1080/14767058.2020.1858278
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Levy,CarolJ
中科院分区：
文献类型：
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作者：
Polsky,Sarit;Foster,NicoleC;DuBose,StephanieN;Agarwal,Shivani;Lyons,Sarah;Peters,AnneL;Uwaifo,GabrielI;DiMeglio,LindaA;Sherr,JenniferL;Levy,CarolJ
目的评估基于胎次的1型糖尿病（T1D）女性糖尿病并发症的危险因素和发生率。研究设计/方法数据收集自2011-2013年和2016-2018年T1D交流中完成妊娠/分娩问卷的女性（16-40岁）。比较入组1年内首次怀孕的妇女（n= 28）和第5年未怀孕的妇女（n= 469）的危险因素和糖尿病并发症的发生率。结果与未分娩妇女相比，已分娩妇女有较低的HbA1c（调整值= .14）和较高的超重/肥胖、甘油三酯/高密度脂蛋白bbb2、log（甘油三酯/高密度脂蛋白）和高血压率的趋势。晚期肾病、蛋白尿或心血管疾病的发生率无显著差异。结论分娩后4 -5年，与未分娩妇女相比，T1D分娩妇女的HbA1c水平较低，但体重指数较高，不良血脂和高血压更常见。基于这些趋势的进一步研究是有必要的。
ObjectivesTo assess risk factors and incidence of diabetes complications in women with type 1 diabetes (T1D) based on parity.Research design/methodsData were collected from women (16–40 years old) in the T1D Exchange completing pregnancy/childbirth questionnaires during 2011–2013 and 2016–2018. Incidence of risk factors and diabetes complications were compared between women with a first pregnancy at/within 1-year of enrollment (n= 28) and never pregnant women by year 5 (n= 469).ResultsThere was a trend for lower HbA1c (adjustedp= .14) and higher rates of overweight/obesity, triglyceride/HDL > 2, log (triglyercide/HDL), and hypertension among parous women compared with nulliparous women. There were no significant differences in rates of advanced nephropathy, albuminuria or cardiovascular disease.ConclusionsFour-5 years after delivery, parous women with T1D tended to have lower HbA1c levels despite higher body mass indices and more frequent adverse lipid profiles and hypertension compared with nulliparous women. Further studies based on these trends are warranted.