Solid-phase synthesis of phenols and pyridinones via arylboronation/oxidation protocol using aryl bromides
Solid-phase synthesis of phenols and pyridinones via arylboronation/oxidation protocol using aryl bromides
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DOI：
10.1016/j.tetlet.2006.05.034
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发表时间：
2006-07-12
影响因子：
1.8
通讯作者：
Kelly, Martha J.
中科院分区：
文献类型：
--
作者：
Lee, Younghee;Kelly, Martha J.
一系列的两个已知的反应，钯催化的芳基硼化的芳基溴化物和随后的氧化的芳基硼酸酯与过硫酸氢钾，已经进行了制备官能化的苯酚和吡啶-2（1H）-酮，随后负载到树脂上的固相合成。使用这些树脂结合的模板，一些固相方法被开发，以产生库的取代苯酚和吡啶-2（1H）-酮。(c)2006爱思唯尔有限公司保留所有权利。
A sequence of two known reactions, palladium catalyzed arylboronation of arybromide and subsequent oxidation of arylboronate with oxone, has been carried out to prepare functionalized phenols and pyridin-2(1H)-one which were later loaded on to resin for solid-phase synthesis. Using these resin-bound templates, a number of solid-phase methods were developed to generate libraries of substituted phenols and pyridin-2(1H)-one. (c) 2006 Elsevier Ltd. All rights reserved.