COLONIC NECROSIS FOLLOWING SODIUM POLYSTYRENE SULFONATE (KAYEXALATE(R))-SORBITOL ENEMA IN A RENAL-TRANSPLANT PATIENT - REPORT OF A CASE AND REVIEW OF THE LITERATURE
COLONIC NECROSIS FOLLOWING SODIUM POLYSTYRENE SULFONATE (KAYEXALATE(R))-SORBITOL ENEMA IN A RENAL-TRANSPLANT PATIENT - REPORT OF A CASE AND REVIEW OF THE LITERATURE
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DOI：
10.1007/bf02049870
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发表时间：
1993-06-01
影响因子：
3.9
通讯作者：
BARTLETT, ST
中科院分区：
文献类型：
--
作者：
SCOTT, TR;GRAHAM, SM;BARTLETT, ST
作者提出的情况下，病人谁发展近全结肠坏死肾移植后不久。症状的发作在时间上与聚苯乙烯钠（Kayexalate(R)）的使用有关；赛诺菲温斯洛普制药公司（Sanofi Winthrop Pharmaceuticals, New York， NY）-山梨醇灌肠剂用于治疗高钾血症。文献中报道了三个类似的病例。尿毒症的存在和山梨糖醇的使用似乎是这种并发症病理生理的共同特征。建议肾移植患者避免使用Kayexalate(R)-山梨醇灌肠剂。
The authors present the case of a patient who developed near total colonic necrosis shortly after renal transplantation. The onset of symptoms was temporally related to the administration of sodium polystyrene (Kayexalate(R); Sanofi Winthrop Pharmaceuticals, New York, NY)-sorbitol enemas for treatment of hyperkalemia. Three similar cases have been reported in the literature. The presence of uremia and the use of sorbitol appear to be common denominators in the pathophysiology of this complication. It is suggested that Kayexalate(R)-sorbitol enemas be avoided in renal transplant patients.