Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia
Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia
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DOI：
10.1073/pnas.061021998
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发表时间：
2001-04-10
影响因子：
11.1
通讯作者：
Yolken, RH
中科院分区：
文献类型：
--
作者：
Karlsson, H;Bachmann, S;Yolken, RH
精神分裂症是一种病因不明的严重脑部疾病，根据临床和流行病学观察，推测逆转录病毒在某些精神分裂症病例的发病机制中的作用。我们在 35 名新近发病的精神分裂症或分裂情感障碍患者中的 10 名 (29%) 患者的无细胞脑脊液 (CSF) 中发现了与逆转录病毒 pol 基因同源的序列，在 20 名慢性精神分裂症患者中的 1 名患者的 CSF 中也发现了逆转录病毒序列，然而，在从 22 名患者获得的任何 CSF 中均未发现逆转录病毒序列。个人 患有非炎症性神经系统疾病或来自 30 名没有神经或精神疾病证据的个体（chi (2) = 19.25，P < 0.001），在患有精神分裂症或分裂情感性障碍的个体的 CSF 中鉴定的核苷酸序列与人内源性逆转录病毒 (HERV)-W 家族的内源性逆转录病毒以及其他逆转录病毒相关。 鼠白血病病毒属。与没有精神疾病的个体的相应组织相比，在精神分裂症个体死后获得的大脑额叶皮层区域中，与反转录病毒HERV-W家族成员同源的RNA转录也被发现有差异上调。中枢神经系统内某些逆转录病毒元件的转录激活可能与至少某些个体的精神分裂症的发展有关。精神分裂症患者中枢神经系统内逆转录病毒成分的进一步表征可能会导致该疾病的诊断和治疗方法的改进。
Schizophrenia is a serious brain disease of uncertain etiology, A role for retroviruses in the etiopathogenesis of some cases of schizophrenia has been postulated on the basis of clinical and epidemiological observations. We found sequences homologous to retroviral pol genes in the cell-free cerebrospinal fluids (CSFs) of 10 of 35 (29%) individuals with recent-onset schizophrenia or schizoaffective disorder, Retroviral sequences also were identified in the CSFs of 1 of 20 individuals with chronic schizophrenia, However, retroviral sequences were not identified in any of the CSFs obtained from 22 individuals with noninflammatory neurological diseases or from 30 individuals without evidence of neurological or psychiatric diseases (chi (2) = 19.25, P < 0.001), The nucleotide sequences identified in the CSFs of the individuals with schizophrenia or schizoaffective disorder were related to those of the human endogenous retroviral (HERV)-W family of endogenous retroviruses and to other retroviruses in the murine leukemia virus genus. Transcription of RNA homologous to members of the HERV-W family of retroviruses also was found to be up-regulated differentially in the frontal cortex regions of brains obtained postmortem from individuals with schizophrenia, as compared with corresponding tissue from individuals without psychiatric diseases, The transcriptional activation of certain retroviral elements within the central nervous system may be associated with the development of schizophrenia in at least some individuals. The further characterization of retroviral elements within the central nervous system of individuals with schizophrenia might lead to improved methods for the diagnosis and management of this disorder.