Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults
Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults
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DOI：
10.1016/j.vaccine.2007.06.066
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发表时间：
2007-09-17
期刊：
影响因子：
5.5
通讯作者：
Frey, Sharon E.
中科院分区：
文献类型：
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作者：
Belshe, Robert B.;Newman, Frances K.;Frey, Sharon E.
本研究采用等剂量ID和IM加标准全剂量IM进行对照，以评估疫苗接种途径在灭活流感疫苗免疫原性中的作用。本研究是一项前瞻性、随机、活性对照、开放标签临床试验，在健康年轻成人门诊患者中进行，以比较途径（IM与ID）对流感疫苗抗体应答的影响。志愿者通过ID或IM途径接受3、6或9 μ g疫苗;还研究了15 μ g IM。通过任一途径给予的低剂量疫苗的免疫原性几乎与标准15 μ g IM剂量的流感疫苗相同。ID途径在诱导抗体方面并不优于IM疫苗上级。ID疫苗诱导的局部炎症反应明显多于IM疫苗。(c)2007爱思唯尔有限公司保留所有权利。
The present study was undertaken with controls using equal doses ID and IM plus the standard full dose IM to assess the role of route of vaccine in immunogenicity of inactivated influenza vaccine. The study was a prospective, randomized, active-controlled, open label clinical trial conducted in healthy young adult outpatients to compare the effect of route (IM versus ID) on antibody responses to influenza vaccine. Volunteers received 3, 6 or 9 mu g of vaccine by ID or IM route; 15 mu g IM was also studied. Low doses of vaccine given by either route were almost as immunogenic as the standard 15 jig IM dose of influenza vaccine. ID route was not superior to IM vaccine at inducing antibodies. ID vaccine induced significantly more local inflammatory response than IM vaccine. (c) 2007 Elsevier Ltd. All rights reserved.