Detection of a human melanoma‐associated antigen, p97, in histological sections of primary human melanomas
Detection of a human melanoma‐associated antigen, p97, in histological sections of primary human melanomas
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在原发性人类黑色素瘤的组织学切片中检测人类黑色素瘤相关抗原 p97
DOI：
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发表时间：
1982
影响因子：
6.4
通讯作者：
K. E. Hellstroum
中科院分区：
文献类型：
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作者：
H. J. Garrigues;H. J. Garrigues;H. J. Garrigues;W. Tilgen;W. Tilgen;I. Hellstrōm;I. Hellstrōm;I. Hellstrom;W. Franke;K. E. Hellstroum;K. E. Hellstroum;K. E. Hellstroum
使用Sternberger的未标记抗体技术研究人黑素瘤相关抗原p97在组织切片中的定位，该抗原由单克隆抗体定义。10例原发性皮肤黑色素瘤中8例、7例转移性黑色素瘤中6例、2例混合痣中2例检测到抗原。它定位于细胞表面，细胞质和细胞核始终为阴性。在来自3例基底细胞癌、1例鳞状细胞癌、1例平滑肌肉瘤的细胞或正常皮肤（包括角质形成细胞、由胶原纤维和弹性纤维组成的结缔组织、成纤维细胞、皮脂腺、血管、平滑肌或炎性细胞如粒细胞、淋巴细胞和巨噬细胞）、肾或肺的样品中未观察到抗原。但2例患者外泌汗腺分泌段的一些细胞染色，可能对应于肌上皮细胞。抗原表达在来自不同黑素瘤的细胞之间以及来自相同黑素瘤的单个细胞之间有些可变。可能的诊断价值，这一程序的黑色素瘤的识别和分类进行了讨论。
The unlabelled antibody technique of Sternberger was used to study the localization in histological sections of human melanoma‐associated antigen p97, which is defined by a monoclonal antibody. The antigen was detected in 8 of 10 primary skin melanomas, in 6 of 7 metastatic melanomas and in 2 of 2 compound nevi. It was localized at the cell surface, the cytoplasm and the nucleus always being negative. The antigen was not seen in cells from 3 basal cell carcinomas, I squamous cell carcinoma, I leiomyosarcoma, or in samples of normal skin (including keratinocytes, connective tissue consisting of collagenous and elastic fibers, fibroblasts, sebaceous glands, blood vessels, smooth muscles, or inflammatory cells such as granulocytes, lymphocytes and macrophages), kidney or lung. There was, however, staining of some cells in the secretory segment of eccrine sweat glands from 2 patients, possibly corresponding to myoepithelial cells. Antigen expression was somewhat variable between cells from different melanomas as well as between individual cells from the same melanoma. The possible diagnostic value of this procedure for identification and classification of melanomas is discussed.
抗体导向的细胞毒剂：使用单克隆抗体引导毒素A链作用于结直肠癌细胞。
DOI：
10.1073/pnas.77.8.4539
发表时间：
1980
影响因子：
11.1
作者：
Gilliland,DG;Steplewski,Z;Collier,RJ;Mitchell,KF;Chang,TH;Koprowski,H
通讯作者：
Koprowski,H
人类黑色素瘤相关抗原：碳水化合物在脱落和细胞表面表达中的作用。
DOI：
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发表时间：
1981
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
MorganJr,AC;Galloway,DR;Imai,K;Reisfeld,RA
通讯作者：
Reisfeld,RA
使用单克隆抗体来确定鼠属病毒粒子和乳腺肿瘤中乳腺肿瘤病毒基因产物的多样性。
影响因子：
11.2
作者：
Colcher,D;HoranHand,P;Teramoto,YA;Wunderlich,D;Schlom,J
通讯作者：
Schlom,J