IL-1β and the Intestinal Epithelial Tight Junction Barrier.
IL-1β and the Intestinal Epithelial Tight Junction Barrier.
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DOI：
10.3389/fimmu.2021.767456
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发表时间：
2021
影响因子：
7.3
通讯作者：
Ma TY
中科院分区：
文献类型：
--
作者：
Kaminsky LW;Al-Sadi R;Ma TY
肠上皮紧密连接（TJ）屏障控制内容物从肠腔进入肠组织和体循环的细胞旁渗透。有缺陷的肠TJ屏障已被认为是肠道炎性疾病（包括克罗恩病、溃疡性结肠炎、坏死性小肠结肠炎和乳糜泻）的重要致病因素。先前的研究表明，在肠道炎症过程中产生的促炎细胞因子，包括白细胞介素-1 β（IL-1β）、肿瘤坏死因子-α和干扰素-γ，具有重要的肠道TJ屏障调节作用。最近的研究表明，IL-1β诱导的肠道TJ通透性增加是肠道炎症的重要促发因素。IL-1β诱导的肠道TJ通透性增加是由调节信号通路和核转录因子核因子-κB激活、肌球蛋白轻链激酶基因激活以及microRNA对转录后occludin基因的调节介导的，并有助于肠道炎症过程。本文就IL-1β对肠道TJ屏障的调节作用、IL-1β调节肠道TJ通透性的细胞内机制以及TJ屏障的潜在治疗靶点进行了综述。
The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation. A defective intestinal TJ barrier has been implicated as an important pathogenic factor in inflammatory diseases of the gut including Crohn’s disease, ulcerative colitis, necrotizing enterocolitis, and celiac disease. Previous studies have shown that pro-inflammatory cytokines, which are produced during intestinal inflammation, including interleukin-1β (IL-1β), tumor necrosis factor-α, and interferon-γ, have important intestinal TJ barrier-modulating actions. Recent studies have shown that the IL-1β-induced increase in intestinal TJ permeability is an important contributing factor of intestinal inflammation. The IL-1β-induced increase in intestinal TJ permeability is mediated by regulatory signaling pathways and activation of nuclear transcription factor nuclear factor-κB, myosin light chain kinase gene activation, and post-transcriptional occludin gene modulation by microRNA and contributes to the intestinal inflammatory process. In this review, the regulatory role of IL-1β on intestinal TJ barrier, the intracellular mechanisms that mediate the IL-1β modulation of intestinal TJ permeability, and the potential therapeutic targeting of the TJ barrier are discussed.
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影响因子：
2
作者：
Bhatia, Amina M.;Stoll, Barbara J.;Hamrick, Shannon E.
通讯作者：
Hamrick, Shannon E.
DOI：
10.1016/j.jconrel.2018.09.003
发表时间：
2018-10-28
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Almansour K;Taverner A;Turner JR;Eggleston IM;Mrsny RJ
通讯作者：
Mrsny RJ
影响因子：
4.8
作者：
Chen, Meng;Zhang, Wenwu;Herring, B. Paul
通讯作者：
Herring, B. Paul
影响因子：
4.4
作者：
Al-Sadi, Rana;Guo, Shuhong;Ma, Thomas Y.
通讯作者：
Ma, Thomas Y.
影响因子：
5.3
作者：
Al-Sadi R;Ye D;Said HM;Ma TY
通讯作者：
Ma TY