Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects
Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects
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DOI：
10.2337/dc05-2565
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发表时间：
2006-06-01
期刊：
影响因子：
16.2
通讯作者：
Ravussin, Eric
中科院分区：
文献类型：
--
作者：
Larson-Meyer, D. Enette;Heilbronn, Leonie K.;Ravussin, Eric
目的-这篇文章的目的是确定总体脂、内脏脂肪组织（VAT）、脂肪细胞大小（FCS）、肝脏异位脂肪沉积之间的关系（肝内脂质[IHL]）和肌肉（肌细胞内脂质[IMCL]）和胰岛素敏感性指数（Si），葡萄糖耐受性受试者以及单独通过饮食或结合运动限制热量对这些变量的影响。研究设计和方法：48名超重志愿者被随机分配到四组：对照组（100%的能量需求），25%的热量限制（CR），12.5%的热量限制+12.5%的能量消耗通过结构化运动（CREX），或15%的体重减轻低热量饮食，然后保持体重6个月（LCD）。在基线和6个月时评估体重、体脂百分比、VAT、IMCL、IHL、FCS和Si。结果基线时，FCS与VAT和IHL相关（P < 0.05），但与IMCL无关。FCS也是S-i的最强决定因素（P < 0.01）。第6个月时的体重减轻为1 +/- 1%（对照，平均值- SE）、10 +/- 1%（CR）、10 +/- 1%（CREX）和14 +/- 1%（LCD）。三个干预组的VAT、FCS、体脂百分比和IHL均降低（P < 0.01），但IMCL无变化。CREX组（37 +/- 18%）和LCD组（70 +/- 34%）在第6个月时增加（P = 0.05）（P < 0.05），CR组有增加趋势（40 +/-20%，P = 0.08）。总之，改善S-I相关的重量，脂肪量和VAT的损失，但不是IHL，IMCL，或FCS.CONCLUSIONS -大脂肪细胞导致脂质沉积在内脏和肝组织，促进胰岛素抵抗。仅通过饮食或运动来限制卡路里，可以逆转这一趋势。
OBJECTIVE - The purpose of this article was to determine the relationships among total body fat, visceral adipose tissue (VAT), fat cell size (FCS), ectopic fat deposition in liver (intrahepatic lipid [IHL]) and muscle (intramyocellular lipid [IMCL]), and insulin sensitivity index (S,) in healthy overweight, glucose-tolerant subjects and the effects of calorie restriction by diet alone or in conjunction with exercise on these Variables. RESEARCHDESIGN AND METHODS - Forty-eight overweight Volunteers were randomly assigned to four groups: control (100% of energy requirements), 25% calorie restriction (CR), 12.5% calorie restriction +12.5% energy expenditure through structured exercise (CREX), or 15% weight loss by a low-calorie diet followed by weight maintenance for 6 months (LCD). Weight, percent body fat, VAT, IMCL, IHL, FCS, and Si were assessed at baseline and month 6.RESULTS - At baseline, FCS was related to VAT and IHL (P < 0.05) but not to IMCL. FCS was also the strongest determinant of S-i (P < 0.01). Weight loss at month 6 was 1 +/- 1% (control, mean - SE), 10 +/- 1% (CR), 10 +/- 1% (CREX), and 14 +/- 1% (LCD). VAT, FCS, percent body fat, and IHL were reduced in the three intervention groups (P < 0.01), but IMCL was unchanged. S, was increased at month 6 (P = 0.05) in the CREX (37 +/- 18%) and LCD (70 +/- 34%) groups (P < 0.05) and tended to increase in the CR group (40 +/- 20%, P = 0.08). Together the improvements in S-i were related to loss in weight, fat mass, and VAT, but not IHL, IMCL, or FCS.CONCLUSIONS - Large adipocytes lead to lipid deposition in Visceral and hepatic tissues, promoting insulin resistance. Calorie restriction by diet alone or with exercise reverses this trend.