Caenorhabditis elegans as a model to study renal development and disease:: Sexy cilia
Caenorhabditis elegans as a model to study renal development and disease:: Sexy cilia
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DOI：
10.1681/asn.2004080645
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发表时间：
2005-02-01
影响因子：
13.6
通讯作者：
Barr, MM
中科院分区：
文献类型：
--
作者：
Barr, MM
秀丽隐杆线虫本身没有肾脏，但“蠕虫”已被证明是研究肾脏相关问题的极好模型，包括排泄管的小管形成、膜转运和离子通道功能，以及包括常染色体显性多囊肾病（ADPKD）在内的人类遗传疾病。这篇综述的目的是解释C. elegans为纤毛发育、纤毛功能和人类囊性肾病提供了深入见解。
The nematode Caenorhabditis elegans has no kidney per se, yet "the worm" has proved to be an excellent model to study renal-related issues, including tubulogenesis of the excretory canal, membrane transport and ion channel function, and human genetic diseases including autosomal dominant polycystic kidney disease (ADPKD). The goal of this review is to explain how C. elegans has provided insight into cilia development, cilia function, and human cystic kidney diseases.