Effect of eucalyptus extract chewing gum on periodontal health: A double-masked, randomized trial
Effect of eucalyptus extract chewing gum on periodontal health: A double-masked, randomized trial
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DOI：
10.1902/jop.2008.070622
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发表时间：
2008-08-01
影响因子：
4.3
通讯作者：
Shizukuishi, Satoshi
中科院分区：
文献类型：
--
作者：
Nagata, Hideki;Inagaki, Yoshika;Shizukuishi, Satoshi
背景：体外研究表明，桉树提取物对龋齿菌和牙周病菌具有抗菌活性；然而，关于人类牙周健康的临床效果仍未得到证实。本研究的目的是在一项双盲、随机、对照试验中评估含有桉树提取物的口香糖对牙周健康的影响。方法：将患有牙龈炎但牙周袋不深的健康人随机分为以下组：高浓度组（n = 32）：使用0.6%桉树提取物口香糖12周（90 mg/天）；低浓度组（n = 32）：使用0.4%桉树提取物口香糖12周（60 mg/天）；安慰剂组（n = 33）：使用不含桉树提取物的口香糖12周。在第0、4、8、12和14周分别测量牙菌斑积累（PLA）、牙龈指数（GI）、探诊出血（BOP）、牙周探诊深度（PD）和临床附着水平（CAL）。显著性分析采用重复测量的双向方差分析，然后采用Games-Howell两两比较检验。结果：桉树提取物口香糖与摄入时间之间的相互作用对PLA、GI、BOP和PD有统计学意义，但对CAL没有统计学意义。与安慰剂组相比，低浓度组和高浓度组在PLA、GI、BOP和PD方面表现出统计学意义（P < 0.05）的改善。结论：桉树提取物口香糖对PLA、GI、BOP和PD有显著影响。使用桉树提取物口香糖可以促进牙周健康。
Background: Studies in vitro showed that eucalyptus extracts possess antibacterial activity against cariogenic and periodontopathic bacteria; however, the clinical effects with respect to periodontal health in humans remain unproven. The objective of this study was to evaluate the effect of chewing gum containing eucalyptus extract on periodontal health in a double-masked, randomized, controlled trial.Methods: Healthy humans with gingivitis but not deep periodontal pockets were randomly assigned to the following groups: high-concentration group (n = 32): use of 0.6% eucalyptus extract chewing gum for 12 weeks (90 mg/day); low-concentration group (n = 32): use of 0.4% eucalyptus extract chewing gum for 12 weeks (60 mg/day); and placebo group (n = 33): use of chewing gum without eucalyptus extract for 12 weeks. Plaque accumulation (PLA), gingival index (GI), bleeding on probing (BOP), periodontal probing depth (PD), and clinical attachment level (CAL) were measured at weeks 0, 4, 8, 12, and 14. Significance was analyzed with repeated-measures two-way analysis of variance followed by the Games-Howell pairwise comparison test.Results: The interaction between the effects of eucalyptus extract chewing gum and the intake period was statistically significant for PLA, GI, BOP, and PD but not for CAL. The low- and high-concentration groups exhibited statistically significant (P < 0.05) improvements compared to the placebo group for PLA, GI, BOP, and PD.Conclusions: Eucalyptus extract chewing gum had a significant effect on PLA, GI, BOP, and PD. The use of eucalyptus extract chewing gum may promote periodontal health.