Preparation and characterization of Ng-mono-, di- and trimethylated arginines.
Preparation and characterization of Ng-mono-, di- and trimethylated arginines.
复制标题
Ng-单、二和三甲基化精氨酸的制备和表征。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
L. Patthy
中科院分区：
文献类型：
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作者：
A. Patthy;S. Bajusz;L. Patthy
介绍了一种合成n -胍基甲基化精氨酸的简单方法。所有甲基精氨酸的产率都超过了以前的方法。三甲基精氨酸——一种在天然来源中找不到的氨基酸——也用这种技术合成了。对精氨酸特异性二羰基试剂的研究表明，胍基甲基化降低了甲基精氨酸的反应活性，只有单甲基精氨酸的反应速率与精氨酸相当。
A simple procedure is described for the synthesis of N-guanidino methylated ariginines. The yields of all methylarginines exceed those obtained by earlier procedures. Trimethylarginine - an amino acid not found in natural sources - has also been synthesized with this technique. Studies with arginine specific dicarbonyl reagents showed that methylation of guanidino-groups decreases the reactivity of methyl-arginines, only monomethylarginine reacting at a rate comparable to that of arginine.