FAILURE OF DIETARY-FAT INTAKE TO PROMOTE FAT OXIDATION - A FACTOR FAVORING THE DEVELOPMENT OF OBESITY
FAILURE OF DIETARY-FAT INTAKE TO PROMOTE FAT OXIDATION - A FACTOR FAVORING THE DEVELOPMENT OF OBESITY
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DOI：
10.1093/ajcn/50.2.307
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发表时间：
1989-08-01
影响因子：
7.1
通讯作者：
JEQUIER, E
中科院分区：
文献类型：
--
作者：
SCHUTZ, Y;FLATT, JP;JEQUIER, E
七个年轻人花了三个晚上和2天的呼吸室，他们的能量消耗和底物氧化率连续测量间接量热法。在最初的24小时内，他们摄入了含有35%卡路里的脂肪混合维持饮食。额外的106 .+-。6 g脂肪/24 h（.hivin.x .+-. SD）在随后的36小时内添加到该饮食中。脂肪补充剂（987 .+-. 55千卡/天）不改变24小时能量消耗（2783 . ±. 232对2820 .+-. 284千卡/天）并且未能促进脂肪作为代谢燃料的使用（脂肪氧化1032 . ±. 205对1042 .+-. 205千卡/天）。总能量平衡与脂肪平衡密切相关（r = 0.96，p < 0.001），但与碳水化合物平衡无关（r =-0.12，NS）。这些数据表明，摄入量和氧化之间的实质性不平衡更可能是脂肪比碳水化合物。
Seven young men spent three nights and 2 d in a respiration chamber where their rates of energy expenditure and substrate oxidation were continuously measured by indirect calorimetry. During the first 24 h they ingested a mixed maintenance diet containing 35% of calories as fat. An additional amount of 106 .+-. 6 g fat/24 h (.hivin.x .+-. SD) was added to this diet during the following 36 h. The fat supplement (987 .+-. 55 kcal/d) did not alter 24-h energy expenditure (2783 .+-. 232 vs 2820 .+-. 284 kcal/d) and failed to promote the use of fat as a metabolic fuel (fat oxidation 1032 .+-. 205 vs 1042 .+-. 205 kcal/d). The overall energy balance was closely correlated with fat balance (r = 0.96, p < 0.001) but not with the carbohydrate balance (r =-0.12, NS). These data indicate that substantial imbalances between intake and oxidation are much more likely for fat than for carbohydrate.