Effects of aging on angiogenesis.
Effects of aging on angiogenesis.
复制标题
衰老对血管生成的影响。
DOI：
10.1161/circresaha.111.246116
复制
发表时间：
2012-04-27
影响因子：
20.1
通讯作者：
Rosenzweig A
中科院分区：
文献类型：
--
作者：
Lähteenvuo J;Rosenzweig A
衰老是大多数心血管疾病的主要危险因素。血管生成受损和内皮功能障碍可能导致老年人心血管疾病及其不良后遗症的患病率增加。血管生成是机体对生理应激的一种重要适应性反应，也是缺血性损伤后的一种内源性修复机制。此外，诱导血管生成是一种有前途的治疗缺血性疾病的方法。由于这些原因，了解与年龄相关的血管生成和内皮功能受损的基础对于理解和管理心血管疾病具有重要意义。在这篇综述中，我们讨论了老年人血管生成受损的分子机制，以及改善老年患者血管功能和血管生成的潜在治疗方法。
Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to physiological stress and an endogenous repair mechanism after ischemic injury. In addition, induction of angiogenesis is a promising therapeutic approach for ischemic diseases. For these reasons, understanding the basis of age-related impairment of angiogenesis and endothelial function has important implications for understanding and managing cardiovascular disease. In this review we discuss the molecular mechanisms that contribute to impaired angiogenesis in the elderly and potential therapeutic approaches to improving vascular function and angiogenesis in aging patients.